STUDY OF A MARKER OF MICROBIAL CONTAMINATION – UREASE ACTIVITY IN THE ORAL FLUID OF PATIENTS FOLLOWING SURGICAL INTERVENTION FOR TUMOUR REMOVAL AND CHEMOTHERAPY AGAINST THE BACKDROP OF A THERAPEUTIC AND PREVENTIVE COMPLEX

Authors:

Abstract:

The study was devoted to the evaluation of the effect of a therapeutic complex of drugs on the marker of microbial contamination in the oral cavity – urease activity in the oral fluid of patients after surgical removal of tumors and chemotherapy. Thirty-five adults (25–55 years) were enrolled: a healthy control cohort, a comparison group receiving only standard oncologic care, and a main group receiving standard care plus the therapeutic and preventive complex. Non-stimulated whole saliva was collected at baseline and at 1, 3, 6, and 12 months post-surgery. Urease activity was quantified. Results were analysed with Student’s t-test (p<0.01). The obtained findings indicate that adjunctive administration of the proposed therapeutic-prophylactic complex effectively reduces bacterial contamination of the oral cavity in patients with head and neck cancer after surgery and chemotherapy, thereby supporting the protective potential of this regimen in the correction of therapy-associated oral dysbiosis.

Keywords:

head and neck tumours urease oral fluid therapeutic and preventive complex

References:

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 67-71
УДК [616-053.88+616-006.04]:616.31-08-039.71

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-67-71