MICROSCOPIC CHANGES IN THE VESSELS OF THE HEMOMICROCIRCULATORY BED OF THE CEREBRAL CORTEX UNDER EXPERIMENTAL CARCINOGENESIS

Authors:

Abstract:

Colorectal carcinogenesis remains one of the major challenges in experimental and clinical oncology. The aim of the study was to investigate morphological changes in the hemomicrocirculatory bed of the cerebral cortex in rats under conditions of experimental carcinogenesis. The study was performed on 30 outbred male white rats. The animals were divided into two groups: Group I consisted of 10 intact control animals, whereas Group II included 20 rats with experimentally induced colorectal adenocarcinoma in situ. Colorectal adenocarcinoma was induced using N,N-dimethylhydrazine hydrochloride dissolved in isotonic sodium chloride solution. The carcinogen was administered subcutaneously into the interscapular region at a dose of 7.2 mg/kg body weight once weekly for 30 weeks. It was established that experimental carcinogenesis induced pronounced alterative changes in the vessels of the microcirculatory bed of the cerebral cortex. Histologically, these alterations were manifested by uneven blood filling, blood stasis, erythrocyte sludge formation, and microthrombosis. Microvessels exhibited irregular blood filling, with signs of either dilation or marked vasospasm. The most prominent change was increased vascular permeability accompanied by the development of severe perivascular edema. The basement membrane was unevenly thickened, edematous, or condensed. Endothelial cells were swollen and vacuolated, exhibited hyperchromatic nuclei, and showed signs of desquamation.

Keywords:

hemocapillaries arterioles venules microcirculatory system histological changes cerebral cortex carcinogenesis

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Publication:

«World of Medicine and Biology» Vol. 22 No. 96 (2026) , с. 155-159
УДК 616.831-018.4:616-092.9:616-006-091.8:611.018.74

DOI:

https://doi.org/10.26724/2079-8334-2026-2-96-155-159