COMPARATIVE EVALUATION OF BIOPSY METHODS IN PRE- AND POSTMENOPAUSAL WOMEN WITH ENDOMETRIAL PATHOLOGY
Clinical medicine

COMPARATIVE EVALUATION OF BIOPSY METHODS IN PRE- AND POSTMENOPAUSAL WOMEN WITH ENDOMETRIAL PATHOLOGY

Published 2024-08-28

Authors:

L.Z. Mammadli
I.Sh. Mahalov
G.I. Babayeva

Abstract:
The study aimed to evaluate the effectiveness of the methods by comparing the histological results obtained using two endometrial sampling methods (endometrial aspiration biopsy using Pipelle and traditional dilatation and curettage) with the histological results of the hysterectomy sample. In total 57 women, both pre- and postmenopausal, who were experiencing abnormal uterine bleeding and postmenopausal bleeding, were examined using two techniques for obtaining endometrial samples. Among the 57 women, 41 experienced perimenopausal uterine bleeding, while 16 presented with postmenopausal uterine bleeding. During the ultrasound examination, endometrial polyps were detected in 19.3 % of cases, uterine fibroids in 73.7 %, and signs of adenomyosis in 35.1 % of patients. Inga ding of sensitivity, Pipelle biopsy, dilatation, and curettage demonstrated detection rates of 30.8 % and 61.5 %, respectively, for identifying endometrial polyps. For cases of endometrial hyperplasia without atypia, these figures were 89.7 %, and 84.6 %, respectively. Notably, both methods exhibited 100 % sensitivity in diagnosing atypical hyperplasia.
Keywords:
dilatation and curettage perimenopausal bleeding Pipelle biopsy endometrial polyps endometrial hyperplasia
References:
  1. Billow MR, El-Nashar SA. Management of Abnormal Uterine Bleeding with Emphasis on Alternatives to Hysterectomy. Obstet Gynecol Clin North Am. 2016 Sep;43(3):415–30. doi: 10.1016/j.ogc.2016.04.002.
  2. Gkrozou F, Dimakopoulos G, Vrekoussis T, Lavasidis L, Koutlas A, Navrozoglou I, et al. Hysteroscopy in women with abnormal uterine bleeding: a meta-analysis on four major endometrial pathologies. Arch Gynecol Obstet. 2015 Jun;291(6):1347–54. doi: 10.1007/s00404-014-3585-x.
  3. Hwang WY, Suh DH, Kim K, No JH, Kim YB. Aspiration biopsy versus dilatation and curettage for endometrial hyperplasia prior to hysterectomy. Diagn Pathol. 2021 Jan 14;16(1):7. doi: 10.1186/s13000-020-01065-0.
  4. Liu H, Wang FL, Zhao YM, Yao YQ, Li YL. Comparison of Pipelle sampler with conventional dilatation and curettage (D&C) for Chinese endometrial biopsy. J Obstet Gynaecol. 2015;35(5):508–11. doi: 10.3109/01443615.2014.970524.
  5. Lytvynenko OV, Hromova AМ, Nesterenko LA, Martynenko VB, Liakhovska TYu. Peculiarities of the course of the postoperative period in women with uterine leiomyoma after uterine artery embolization. World of Medicine and Biology. 2019; 3 (69):105–108. doi: 10.26724/2079-8334-2019-3-69-105-108.
  6. Sanderson PA, Critchley HOD, Williams ARW, Arends MJ, Saunders PTK. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017; 23(2):232–254.
  7. Santiago WS, Silva JBD, Pereira RM, Mascarenhas CDC. Abnormal uterine bleeding: hysterectomy versus resection. Rev Assoc Med Bras (1992). 2020 Dec;66(12):1731–1735. doi: 10.1590/1806-9282.66.12.1731.
  8. Terzic MM, Aimagambetova G, Terzic S, Norton M, Bapayeva G, Garzon S. Current role of Pipelle endometrial sampling in early diagnosis of endometrial cancer. Transl Cancer Res. 2020 Dec; 9(12):7716–7724. doi: 10.21037/tcr.2020.04.20.
  9. Utida GM, Kulak J Jr. Hysteroscopic and aspiration biopsies in the histologic evaluation of the endometrium. a comparative study. Medicine (Baltimore). 2019 Oct; 98(40): e17183. doi: 10.1097/MD.0000000000017183.
  10. Xue H, Shen WJ, Zhang Y. Pathological pattern of endometrial abnormalities in postmenopausal women with bleeding or thickened endometrium. World J Clin Cases. 2022 Mar 6;10(7):2159–2165. doi: 10.12998/wjcc.v10.i7.2159.
  11. Zhao J, Hu Y, Zhao Y, Chen D, Fang T, Ding M. Risk factors of endometrial cancer in patients with endometrial hyperplasia: implication for clinical treatments. BMC Womens Health. 2021 Aug 25;21(1):312. doi: 10.1186/s12905-021-01452-9.
Publication:
«World of Medicine and Biology» Vol. 20 No. 89 (2024) , с. 117-120
УДК 618.14-002.2 (075.8)