ACUTE PERITONITIS AND POSSIBLE CONNECTION WITH 5,10-METHYLENETETRAHYDROFOLATEREDUCTASE GENE POLYMORPHISMS rs1801133 AND rs1801131

Authors:

Abstract:

The purpose of the study was to analyze the condition of patients with acute peritonitis and to establish the connection with polymorphisms of the 5,10-methylenetetrahydrofolate reductase gene rs1801133 and rs1801131. 100 patients who were operated on for peritonitis were divided into three groups by diagnosis: 1st – acute appendicitis (48 %), 2nd – acute cholecystitis (32 %) and 3rd – other diseases (22 %), including perforated stomach ulcer or duodenal (8 %), tumour perforation (3 %), abdominal trauma (3 %), pinched hernia (2 %), and intestinal obstruction (4 %). 50 people without such pathology were involved for control. The allelic polymorphism rs1801133 of the 5,10-methylenetetrahydrofolate reductase gene was connected with the development of peritonitis (except for patients with acute appendicitis): mutant allele A increased the risk of peritonitis compared to controls (OR 1.9; 95 % PI 1.06-3.49; p=0.038). The allelic polymorphism rs1801131 of the 5,10-methylenetetrahydrofolate reductase gene increased the risk of peritonitis in patients with acute appendicitis compared with all other diagnoses (OR 2.03; 95 % PI 1.07-3.84; p=0.039). The results showed that the risk of peritonitis depended on the presence of polymorphisms rs1801133 and rs1801131 of the 5,10-methylenetetrahydrofolate reductase gene.

Keywords:

peritonitis 5 10-methylenetetrahydrofolate reductase rs1801133 rs1801131 multiple organ failure

References:

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Publication:

«World of Medicine and Biology» Vol. 20 No. 88 (2024) , с. 77-81
УДК 616.381-002.1

DOI:

https://doi.org/10.26724/2079-8334-2024-2-88-77-81