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    Polyasny V.A.

    PECULIARITIES OF MICROSOMAL FUNCTION OF LIVER UNDER CONDITIONS OF CHRONIC EPILEPTIC ACTIVITY INDUCTION AND EXPERIMENTAL TREATMENT


    About the author: Polyasny V.A.
    Heading EXPERIMENTAL MEDICINE
    Type of article Научная статья
    Annotation Under conditions of chronic experiment on Wistar rats with corazol- induced (25,0 mg/kg, i.p.) kindling the pronounced disturbances of the activity of cytochrom P450 were registered. Besides, the ratio of Р450/Р420 was decreased, and the activity of cytochrom b5.was decreased. The disturbances in the phospholipids turnover were observed as well and these manifestations were more pronounced in postponed kindling and subthreshold corazol administration. Ketogenic diet and pentoxyphyllin (50,0 mg/kg, i.p.) administration normalized the general content of microsomal phospholipids, and the enhanced the level of lyzophosphat-idilcholine. The preservation of functional activity of cytochrom P450 as well as significant increasing of amidopirin-N- demethylase and anylin-n- hydroxylase activities were observed as well. Besides, the increasing of cytochrom b5.was registered.
    Tags kindling, ketogenic diet, pentoxyphyllin, pospholipids, liver
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    Publication of the article «World of Medicine and Biology» №1(32), 2012 year, 141-144 pages, index UDK 616.37- 002-08