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    Ocheretnyuk А.О., Prokopenko S.V., Chereshnyuk І.L., Lysenko D.А.


    About the author: Ocheretnyuk А.О., Prokopenko S.V., Chereshnyuk І.L., Lysenko D.А.
    Type of article Scentific article
    Annotation The article presents the analysis of the performance of the cell cycle of lungs cells against a background of burning the skin and in the correction of a 0,9 % solution of NaCl, laсtoprotein with sorbitol or HAES-LX 5% at 1, 3 and 7 days after burn skin lesions in rats. It was revealed that the burn damage of the skin accompanied by a significant reduction in DNA synthesis phase indices, normalization which occurs on the 7th day after the defeat. When applied on a background of burn skin lesions lactoprotein with sorbitol in 1 day found a significant increase in proliferation index (PI) and phase G2 + M, and the decline in the G0G1 phase as compared with the group Burn + 0,9% NaCl. On the background of the drug HAES-LX 5% after 3 days after burn skin revealed a strong tendency to decrease proliferation block (p = 0,093) and increased phase G2 + M (p = 0,055) compared with those on day 3 group Burn 0,9% NaCl. Usage of lactoprotein with sorbitol or HAES-LX 5%, 7 days after burn injury of the skin, caused a normalization of cellular cycle of lungs, which was characterized by a decrease of block proliferation index, as well as a positive stimulating effect on DNA synthesis in the application of HAES-LX 5%.
    Tags burns of the skin, cell cycle, DNA cytometry, lungs, HAES-LX 5%, lactoprotein with sorbitol
    • Боенко С. К. Поражение дыхательных путей у обожжённых / С. К. Боенко [и др.]. // – Киев, - 1990. – С. 96-118.
    • Гунас І. В. Наслідки впливу опіку шкіри на показники клітинного циклу клітин тимусу та їх корекція лактопротеїном з сорбітолом або HAES-LX 5 % / І. В. Гунас, Б. О. Кондрацький, Е. В. Черкасов [и др.] // Biomedical and Biosocial Anthropology. – 2012. – C. 135 – 141.
    • Спиридонова Т.Г. Полиорганная дисфункция и недостаточность у обожженных: автореф. дис. на соискание научн. степени доктора мед. наук : 14.00.27, 14.00.17 / Спиридонова Тамара Георгиевна. – М., - 2007. – 41 с.
    • Климов А. Г. Искусственное поддержание газообмена у пострадавших с термической травмой в период ожогового шока: автореф. дис. на соискание научн. степени доктора мед. наук: спец. 14.00.37 / Климов А. Г. – M., - 2010.
    • Фісталь Е. Я. Комбустіологія / Е. Я. Фісталь, Г. П. Козинець, Г. Є. Самойленко [та ін.] // – Київ : “Інтерлінк”. – 2004. – С. 24-26.
    • Dai Z. Ringer's malate solution protects against the multiple organ injury and dysfunction caused by hemorrhagic shock in rats / Z. Dai.[ et al.] // Shock. – 2012. – Vol. 38, № 3. – P. 268-274.
    • Galani V. The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS): an up-to-date cell-specific review / V. Galani, E. Tatsaki, M. Bai [et al.] // Pathol. Res. Pract. – 2010. – Mar 15. – Vol. 206, № 3. – P. 145-150.
    • Li W. The change in apoptosis and proliferation of pulmonary tissue cells in rats with smoke inhalation injury / W. Li, Z. Yang, X. Yang [et al.] Zhonghua Shao Shang Za Zhi. – 2002. – Vol. 3. – P. 139-141.
    • Li W.J. Effects of smoke inhalation injury on the phagocytic function of rat alveolar macrophage and on neutrophil apoptosis / W.J. Li, Z.C. Yang, E.H. Li [et al.] // Article in Chinese. – Zhonghua Shao Shang Za Zhi. – 2003. – Vol. 19(3). – P. 163-166.
    • Matsubar M. Paraquat causes S-phase arrest of rat liver and lung cells in vivo / M. Matsubara, K. Yamagami, Y. Kitazawa [et al.] // Arch. Toxicol. – 1996. – Vol. 70, № 8. – P. 514-518.
    Publication of the article «World of Medicine and Biology» №4(46) 1 part 2014 year, 129-135 pages, index UDK 616-001.17:599.323.4;591.22;576.36