| About the author: |
Ocheretnyuk А.О., Prokopenko S.V., Chereshnyuk І.L., Lysenko D.А. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The article presents the analysis of the performance of the cell cycle of lungs cells against a background of burning the skin and in the correction of a 0,9 % solution of NaCl, laсtoprotein with sorbitol or HAES-LX 5% at 1, 3 and 7 days after burn skin lesions in rats. It was revealed that the burn damage of the skin accompanied by a significant reduction in DNA synthesis phase indices, normalization which occurs on the 7th day after the defeat. When applied on a background of burn skin lesions lactoprotein with sorbitol in 1 day found a significant increase in proliferation index (PI) and phase G2 + M, and the decline in the G0G1 phase as compared with the group Burn + 0,9% NaCl. On the background of the drug HAES-LX 5% after 3 days after burn skin revealed a strong tendency to decrease proliferation block (p = 0,093) and increased phase G2 + M (p = 0,055) compared with those on day 3 group Burn 0,9% NaCl. Usage of lactoprotein with sorbitol or HAES-LX 5%, 7 days after burn injury of the skin, caused a normalization of cellular cycle of lungs, which was characterized by a decrease of block proliferation index, as well as a positive stimulating effect on DNA synthesis in the application of HAES-LX 5%. |
| Tags |
burns of the skin, cell cycle, DNA cytometry, lungs, HAES-LX 5%, lactoprotein with sorbitol |
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| Publication of the article |
«World of Medicine and Biology» №4(46) 1 part 2014 year, 129-135 pages, index UDK 616-001.17:599.323.4;591.22;576.36 |
