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    Ocheretnyuk А.О., Prokopenko S.V., Chereshnyuk І.L., Lysenko D.А.

    СELL CYCLE INDICES OF RATS LUNGS TISSUE CELLS AFTER BURN SKIN LESION


    About the author: Ocheretnyuk А.О., Prokopenko S.V., Chereshnyuk І.L., Lysenko D.А.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The article presents the analysis of the performance of the cell cycle of lungs cells against a background of burning the skin and in the correction of a 0,9 % solution of NaCl, laсtoprotein with sorbitol or HAES-LX 5% at 1, 3 and 7 days after burn skin lesions in rats. It was revealed that the burn damage of the skin accompanied by a significant reduction in DNA synthesis phase indices, normalization which occurs on the 7th day after the defeat. When applied on a background of burn skin lesions lactoprotein with sorbitol in 1 day found a significant increase in proliferation index (PI) and phase G2 + M, and the decline in the G0G1 phase as compared with the group Burn + 0,9% NaCl. On the background of the drug HAES-LX 5% after 3 days after burn skin revealed a strong tendency to decrease proliferation block (p = 0,093) and increased phase G2 + M (p = 0,055) compared with those on day 3 group Burn 0,9% NaCl. Usage of lactoprotein with sorbitol or HAES-LX 5%, 7 days after burn injury of the skin, caused a normalization of cellular cycle of lungs, which was characterized by a decrease of block proliferation index, as well as a positive stimulating effect on DNA synthesis in the application of HAES-LX 5%.
    Tags burns of the skin, cell cycle, DNA cytometry, lungs, HAES-LX 5%, lactoprotein with sorbitol
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    Publication of the article «World of Medicine and Biology» №4(46) 1 part 2014 year, 129-135 pages, index UDK 616-001.17:599.323.4;591.22;576.36