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    Opryshko V. I., Nosivets Dm. S.

    CHANGE OF INTRACENTRAL RELATIONSHIP BETWEEN BRAINE STRUCTURE ON BACKGROUND TO ENTER LAMOTRIGINE WITH ANALGETICS


    About the author: Opryshko V. I., Nosivets Dm. S.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The authors of the article discussed the interaction between anticonvulsant lamotrigine and analgesics in the neurophysiological level. It was found that the decrease in activity (excitability threshold is increased) RF and the cerebral cortex under the influence of analgesics with pro-convulsive component of action in epileptic activity reduces the influence of Rfon DH and DMI, which may underlie the reduction of the anti-siezure action of anticonvulsants (the development of pharmacodynamic antagonism between the drugs).
    Tags analgetics, anticonvulsants, excitability, intracentral relationship
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    Publication of the article «World of Medicine and Biology» №4(47) 2 part 2014 year, 173-177 pages, index UDK 615.212.3/213-092.4:616-071.4:616.853