| About the author: |
Savchuk Z. L. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
To study the influence of experimental hypothyroidism on the state of endogenous intoxication at rats with the chemical burn of cornea markers of endogenous intoxication – molecules of average mass, erythrocyte and leukocyte indices of intoxication were determined. It was also investigated the activity of lysosomal proteases – cathepsin D and acid phosphatase. Hypothyroidism at rats was caused by the injection of merkazolil at a dose of 10 mg/kg for 60 days. Chemical burn of cornea was simulated by the application of filter paper saturated with 1 N NaOH for 30 seconds. Burning injury at rats at the background of hypothyroidism was accompanied by the suppression of the activity of lysosomal enzymes – cathepsin D and acid phosphatase in homogenate of cornea and more intense, as compared with euthyroid animals, markers of endogenous intoxication – molecules of average mass, erythrocyte and leukocyte indices of intoxication. |
| Tags |
chemical burns of the cornea, hypothyroidism, endogenous intoxication |
| Bibliography |
- Ashhekina A.V. Sindrom gipotiroza v praktike terapevta i kardiologa / A.V. Ashhekina // Ross. Med. vesti. – 2008. – T. 2. – S. 42-45.
- Balabolkin M.I. Fundamental'naja i klinicheskaja tiroidologija: rukovodstvo / M.I. Balabolkin, E.M. Klebanova, V.M. Kreminskaja // – M.: Medicina, - 2007. – 816 s.
- Vaceba A.O. Epіdemіologіja zahvorjuvan' shhitopodіbnoї zalozi v umovah jodnoї nedostatnostі / A. O. Vaceba, V. M. Gavriljuk, V. І. Pan'kіv // Lіkar. sprava. – 2002. – № 1. – S. 31-33.
- Gabrijeljan N.I. Opyt ispol'zovanija pokazatelja srednih molekul v krovi dlja diagnostiki nefrologicheskih zabolevanij u detej / N.I. Gabrijeljan, V.I. Lipatova // Lab. delo. – 1984. – № 3 – S. 138-140.
- Dingl Dzh. Metody issledovanija / Dzh. Dingl // – M.: Mir, -1980. – 344 s.
- Kozhem’jakіn Ju.M. Naukovo-praktichnі rekomendacії z utrimannja laboratornih tvarin ta roboti z nimi / Ju.M. Kozhem’jakіn, O.S. Hromov, M.A. Fіlonenko [ta іn.] // – K.: Avіcena, -2002. – 156 s.
- Netjuhajlo L.G. Molekuli seredn'oї masi — markeri endogennoї іntoksikacії pri eksperimental'nіj opіkovіj hvorobі / L.G. Netjuhajlo // Suchasnі problemi toksikologії. – 2005. – №3. – S. 43-46.
- Ostrovskij V.K. Lejkocitarnyj indeks intoksikacii pri ostryh gnojnyh i vospalitel'nyh zabolevanijah legkih / V.K. Ostrovskij, Ju.M. Svitich, V.R. Veber // Vestn. hirurgii im. I.I.Grekova.-1983.-T.131, №11.– S. 21-24.
- Podunaj Ju. A. Vozrastnaja dinamika aktivnosti katepsinov i soderzhanija srednemolekuljarnyh peptidov v myshcah morskogo ersha / Ju.A. Podunaj, I.N. Zalevskaja, I.I. Rudneva // Uchenye zapiski Tavricheskogo nacional'nogo universiteta im. V.I. Vernadskogo. Serija «Biologija, himija». – 2009. – T.22 (61). – № 4.-S.128-134.
- Pan'kіv V.І. Praktichna tireoїdologіja : monografіja / V. І. Pan'kіv // - Donec'k : Zaslavs'kij O.Ju., - 2011. – 224 c.
- Pan'kіv V.І. Profіlaktika jododefіcitnih zahvorjuvan' v Ukraїnі: nastav chas uhvalennja rіshen' / V. І. Pan'kіv // Ukr. zhurn. dit. endokrinologії – 2012. – № 1. – S. 7-12.
- Rom-Bugoslavs'ka O.S. Doklіnіchne vivchennja tireostatichnih ta tireoїd-stimuljujuchih zasobіv / O.S. Rom-Bugoslavs'ka, T.S. Bozhko, І.V. Komarova // Doklіnіchnі doslіdzhennja lіkars'kih zasobіv: Metod. rekomendacії.– Kiїv, - 2001. – S. 409-420.
- Speranskij I.I. Obshhij analiz krovi – vse li ego vozmozhnosti ischerpany? Integral'nye indeksy intoksikacii kak kriterii ocenki tjazhesti techenija jendogennoj intoksikacii, ee oslozhnenij i jeffektivnosti provodimogo lechenija / I.I. Speranskij, G.E. Samojlenko, M.V. Lobacheva // Zdorov'e Ukrainy. – 2009. – № 6 (19). – S. 51-57.
- Togajbaev A. A. Metod opredelenija jendogennoj intoksikacii / A.A. Togajbaev, A.V. Kurguzkin, I.V. Rikun // Lab. delo. – 1988. – № 9. – S. 22-24.
- Titov V. N. Rol' makrofagov v stanovlenii vospalenija, dejstvie interlejkina-1, interlejkina-6 i aktivnost' gipotalamo-gipofizarnoj sistemy / V.N. Titov // Klin. lab. diagn. – 2003. – №12. – S. 3-10.
- Asayama K. Lipid peroxidation and free radical scavengers in thyroid dysfunction in the rat: a possible mechanism of injury to heart and skeletal muscle in hyperthyroidism / K. Asayama, K. Dobashi, H. Hayashibe // Endocrinology. – 1987. – Vol. 121, №2. – P. 112-118.
- Bodansky O. Acid phosphatase / O. Bodansky // Adv. Clin. Chem. – 1972. – Vol.15. – P.143-147.
- Boelen A. Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis / A. Boelen, J. Kwakkel, M. Platvoetter Schiphorst // Eur. J. Endocrinol. – 2004. – Vol. 151, №4. – P. 497-502.
- Isman C.A. Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis / C.A. Isman, B.C. Yegen, I. Alican // J. Endocrinol. – 2003. – Vol. 177, №3. – P. 471-476.
- Mezosi E. Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes / E. Mezosi, J. Szabo, E.V. Nagy // J. Endocrinol. – 2005. – Vol. 185, №1. – P. 121-129.
- Marino F. Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy / F. Marino, L. Guasti, M. Cosentino // Life Sci. – 2006. – Vol. 78, №10. – P. 1071-1077.
- Rao M. K. Extracellular metabolism of thyroid hormones by stimulated granulocytes / M.K. Rao, A.L. Sagone // Infect Immun. – 1984. – Vol. 43, №3. – P. 846-849.
- Tenorio-Velazquez V.M. Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymesactivities. / V.M. Tenorio-Velazquez, D. Barrera, M. Franco // BMC Nephrol. – 2005. – №6. – R.12.
- Wiederanders B. Accumulation of inactive cathepsin D in old rats / B. Wiederanders, B. Oelke // Mech. Ageing Dev. – 1982. – Vol. 24. – № 3. – P. 265-271.
|
| Publication of the article |
«World of Medicine and Biology» №2(50) 2 part 2015 year, 166-171 pages, index UDK 616-002 – 008.953-092 |
