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    A. M. Goltsev, O. O. Lykhytskyi

    PROGNOSIS OF REPARATIVE OSTEOGENESIS IN RATS WITH OPEN MANDIBULAR FRACTURE ON THE BACKGROUND OF OSTEOPOROSIS


    About the author: A. M. Goltsev, O. O. Lykhytskyi
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation In this work, mathematical prediction of the course of reparative osteogenesis in rats with an open fracture of the mandible on the background of osteoporosis has been carried out. It is shown that important biochemical markers for prognosis of osteo-reparation processes under conditions of simulated pathology are the content of VEGF, TGF-β1, carbonyl groups of proteins, nitrites and nitrates in serum. Among these biochemical indicators, the greatest value for controlling the processes of reparative osteoregeneration is the determination of the content of TGF-β1 and VEGF in serum, but less important is the study of the level of carbonyl groups of proteins and nitrites and nitrates in serum.
    Tags metabolic markers, reparative osteogenesis, fracture of the mandible, mathematical prediction
    Bibliography
    • Batura I.A. Osteonnyie konstruktsii bedrennoy kosti kryis pri dlitelnom vvedenii gidrokortizona. Visnyk Bilotserkivs'koho derzhavnoho ahrarnoho universytetu, 2005; 33: 300-304. (in Russian)
    • Fukui T, Ishizaka N, Rajagopalan S, Laursen JB, Capers Q, Taylor WR, Griendling KK. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ. Res., 1997; 80(1): 45-51.
    • Gabrielyan NI, Dmitriev AA, Kulakov GN, Mekikyan AM, Scherbaneva OI. Diagnosticheskaya tsennost opredeleniya srednih molekul v plazme krovi pri nefrologicheskih zabolevaniyah. Klin. med., 1981; 10: 38-42. (in Russian)
    • Kochetov GA. Prakticheskoe rukovodstvo po enzimologii. 1980; M.: Vyissh. shk. (in Russian)
    • Korenman II. Metodyi opredeleniya organicheskih soedineniy. 1975; M.: Himiya. (in Russian)
    • Korzh NA, Deduh NV, Nikolchenko OA. Reparativnaya regeneratsiya kosti: sovremennyiy vzglyad na problemu. Sistemnyie faktoryi, vliyayuschie na zazhivlenie pereloma. (Soobschenie 3). Ortopediya, travmatologiya i protezirovanie,2006;2:93-99. (in Russian)
    • Kostyuk VA, Potapovich AI, Kovaleva ZhV. Prostoy i chuvstvitelnyiy metod opredeleniya aktivnosti superoksiddismutazyi, osnovannyiy na reaktsii okisleniya kvertsitina. Vopr. med. Himii, 1990; 2: 88-91. (in Russian)
    • Levitskiy AP, Makarenko OA, Denga OV, Sukmanskiy OI, Podorozhnaya RP, Rossahanova LN. Eksperimentalnyie metodyi issledovaniya stimulyatorov osteogeneza: metod. rekomendatsii. 2005; K.: GFTs. (in Russian)
    • Menshikov VV. Laboratornyie metodyi issledovaniya v klinike: Spravochnik. 1987; M.: Meditsina. (in Russian)
    • Rolik OV, Zasadnyuk IA. Nezroshchennya dovhykh kistok (analiz, faktory ryzyku, likuval'na taktyka). Ortopedyya, travmatolohyya y protezyrovanye, 2005; 2: 61-64. (in Ukraine)
    • Sharaev PN, Sahabutdinova EP, Lekomtseva OI, Koshikova SV. Opredelenie svobodnogo i peptidno-svyazannogo gidroksiprolina v syivorotke krovi. Klin. labor. dIagnostika, 2009; 1: С. 7-9. (in Russian)
    • Vladimirov YuV, Archakov AI. Perekisnoe okislenie lipidov v biologicheskih membranah. 1972; M.: Nauka. (in Russian)
    • Zaichko NV. Okyslyuvalna modyfikatsiya bilkiv syrovatky krovi yak marker aktyvnosti revmatoyidnoho artrytu ta yiyi zminy pid vplyvom farmakoterapiyi amizonom, indometatsynom, nimesulidom. Visnyk Vinnyts'koho derzhavnoho medychnoho universytetu, 2003; 7(2/2): 664-666. (in Ukraine)
    Publication of the article «World of Medicine and Biology» №1(63), 2018 year, 109-112 pages, index UDK (611.018.4+599.323.4):616.716.4
    DOI 10.26.724/2079-8334-2018-1-63-109-112