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    Cheremisina V. F., Bereznyakova A. I.

    CORRELATION OF CYTOKINE PRODUCTS LEVELS IN REGULATION MECHANISMS OF BONE TISSUE REMODELING PROCESSES IN PARODONTITIS


    About the author: Cheremisina V. F., Bereznyakova A. I.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The levels of production of cytokines and their interrelations in the mechanisms of regulation of bone tissue remodeling processes on the model of periodontitis accompanied by inflammation were studied. The study was carried out on two groups of non-linear white male rats. In the blood serum the levels of RANKL, osteoprotegerin, TGFβ1, IL-1 Ra, adiponectin, visfatin and IL-17 were determined by an enzyme immunoassay. In animals with periodontitis, the levels of RANKL and TGFβ1 decreased and the levels of IL-1 Ra and IL-17 increased. Differences in the nature of the relationship between cytokine levels in the study groups were found. The characteristics of the cytokine profile revealed reflect the end of the active resorption phase initiated by periodontitis and inflammation, and the beginning of the phase of compensatory reactions in bone tissue. The disappearance of interrelations in the system of normal regulation of bone tissue remodeling between pairs of cytokines and their appearance between other pairs testifies to violations in the work of regulatory mechanisms in periodontitis accompanied by inflammation.
    Tags bone tissue, remodeling, cytokines, regulation
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    Publication of the article «World of Medicine and Biology» №2(64), 2018 year, 181-185 pages, index UDK 616.71-007.234-076:616.61-036
    DOI 10.26724/2079-8334-2018-2-64-181-185