L.I. Krasiliuk, R.V. Bakhchiev, M.V. Shostak, A.V. Rudenko

TARGETED PREVENTION OF THE PROSTATE CANCER: FOCUS ON THE CHEMOPREVENTION AGENT AND GROUP OF PATIENTS

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About the author:	L.I. Krasiliuk, R.V. Bakhchiev, M.V. Shostak, A.V. Rudenko
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	The study has been carried out with participation of 24 male patients, who, due to high PSA level and suspicious data previously underwent polyfocal biopsy of the prostate gland. Pathological examination of prostate biopsy samples detected no prostate cancer, high-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation focuses. All the patients were divided into two groups. The main group comprised 14 men, who during 12 months had been taken 2 capsules of nutraceuticals containing 200 mg of indole-3-carbinol (I3C) and 45 mg of epigallocatechin-3-gallate (EGCG) in the mealtime (daily dose of 400 mg I3C and 90 mg EGCG). Patients of the comparison group (10 people) were under observation. Patients of both groups followed behavioral and dietary recommendations throughout the year (recommendations EAU 2016). The LUTS index according to IPSS after 1 year of research decreased by 38.7% in the main group patients, while there were no changes in the comparison group. The total of PSA level significantly decreased by 46.2% only in patients of the main group. The data obtained in the research indicate a significant decrease in the level of PSA and LUTS with long-term use of the combination of I3C and EGCG. The previous research, conducted with the use of multivariate analysis in the molecular genetic diagnosis of preclinical stages of prostate cancer, identified a subcluster of patients with histologically confirmed BPH and the molecular genetic characteristics (as the presence and level of methylation of the promoter zone of the genes GSTP1, APC, RARb), completely relevant to PCa. Patients with histologically confirmed BPH and the molecular genetic characteristics (as the presence and level of methylation of the promoter zone of the genes GSTP1, APC, RARb), completely relevant to PCa, can be ideal focus group for targeted prevention of the development of prostate cancer with various drugs, including nutraceuticals based on I3C and EGCG.
Tags	Targeted prevention; prostate cancer; benign prostatic hyperplasia; prostate specific antigen; indole-3-carbinol; epigallocatechin-3-gallate
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Publication of the article	«World of Medicine and Biology» №4(66), 2018 year, 067-070 pages, index UDK 616.65-006.6-08-039.74:615.28.
DOI	10.26724/2079-8334-2018-4-66-67-70