EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    L.V. Pakharenko, I.T. Kyshakevych, V.D.Vorobii

    IMPACT OF POLYCYSTIC OVARY SYNDROME ON QUALITY OF LIFE OF WOMEN IN EARLY REPRODUCTIVE AGE


    About the author: L.V. Pakharenko, I.T. Kyshakevych, V.D.Vorobii
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation We studied quality of life in 60 women in early reproductive age with polycystic ovary syndrome (PCOS) who formed basic group. 30 women without this pathology were controls. Diagnosis of PCOS was based on the Rotterdam criteria. Ultrasound examination of pelvic organs, sexual steroids hormones, androgens, level of glucose, amount of insulin, lipoproteins were determined in blood serum. Quality of life was studied with help of 36-Item Short Form Health Survey. Average age of patients in basic group was 21.00±0.49 years, in control one – 21.67±0.34. All persons with PCOS had oligomenorrhea, 28.33 % – amenorrhea. Clinical signs of hyperandrogenia had 68.33 % of women in basic group. However, laboratory rise of androgens was determined only in 18.33 % of patients. We founded that increased ratio luteinizing hormone / follicle stimulating hormone more than 2.5 had 61.67 % persons with PCOS. But the amount of antimullerian hormone in blood was high in all patients in basic group. Ultrasound changes of ovarian tissue that indicate PCOS were determined in all women in basic group. 33.33 % of them had increased body mass index versus 16.67 % of controls. But the rate of other metabolical disorders such as insulin resistance, impaired glucose tolerance and lipid metabolism disorders were found only in 18.33 % of persons with PCOS. Scores of the physical component of SF-36 in women of basic group were slightly less than in controls. More pronounces decline was determined in parameters of the psychological component. Especially decrease was found in indices of scores “Vitality” on 15.16 % (p=0.04) and “Social functioning” – on 18.14 % (p=0.02) compared to healthy women. Thus, the decrease of the psychological component of quality of life is typical for patients with PCOS, especially the scores “Vitality” and “Social Functioning”.
    Tags polycystic ovary syndrome, early reproductive age, quality of life
    Bibliography
    • Balikci A, Erdem M, Keskin U, Bozkurt Zincir S, Gülsün M, Özçelik F, et al. Depression, Anxiety, and Anger in Patients with Polycystic Ovary Syndrome. Noro Psikiyatr Ars. 2014 Dec; 51(4): 328-333. doi: 10.5152/npa.2014.6898.
    • Barthelmess EK, Naz RK. Polycystic ovary syndrome: current status and future perspective. Front Biosci (Elite Ed). 2014 Jan 1; 6: 104-19.
    • Behboudi-Gandevani S, Amiri M, Bidhendi Yarandi R, Noroozzadeh M, Farahmand M, Rostami Dovom M, et al. The risk of metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis. Clin Endocrinol (Oxf). 2018 Feb; 88(2): 169-184. doi: 10.1111/cen.13477.
    • Borghi L, Leone D, Vegni E, Galiano V, Lepadatu C, Sulpizio P, et al. Psychological distress, anger and quality of life in polycystic ovary syndrome: associations with biochemical, phenotypical and socio-demographic factors. J Psychosom Obstet Gynaecol. 2017 Apr 6:1-10. doi: 10.1080/0167482X.2017.1311319.
    • Condorelli RA, Calogero AE, Di Mauro M, Mongioi' LM, Cannarella R, Rosta G, et al. Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index. J Endocrinol Invest. 2017 Sep 23. doi: 10.1007/s40618-017-0762-3.
    • Glintborg D, Andersen M. Medical comorbidity in polycystic ovary syndrome with special focus on cardiometabolic, autoimmune, hepatic and cancer diseases: an updated review. Curr Opin Obstet Gynecol. 2017 Dec; 29(6): 390-396. doi: 10.1097/GCO.0000000000000410.
    • Khomami MB, Tehrani FR, Hashemi S, Farahmand M, Azizi F. Of PCOS symptoms, hirsutism has the most significant impact on the quality of life of Iranian women. PLoS One. 2015 Apr 15; 10(4): e0123608. doi: 10.1371/journal.pone.0123608.
    • Panico A, Messina G, Lupoli GA, Lupoli R, Cacciapuoti M, Moscatelli F, et al. Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome. Patient Prefer Adherence. 2017 Mar 2; 11: 423-429. doi: 10.2147/PPA.S119180.
    • Prakansamut N, Sirayapiwat P, Triratanachat S. The percentages of endometrial hyperplasia and endometrial cancer among polycystic ovary syndrome (PCOS) patients presenting with abnormal menstrual pattern. J Med Assoc Thai. 2014 Feb; 97(2): 159-64.
    • Setji TL, Brown AJ. Polycystic ovary syndrome: update on diagnosis and treatment. Am J Med. 2014. Oct; 127 (10): 912–9. doi: 10.1016/j.amjmed.2014.04.017.
    • Shafti V, Shahbazi S. Comparing Sexual Function and Quality of Life in Polycystic Ovary Syndrome and Healthy Women. J Family Reprod Health. 2016 Jun; 10(2): 92-8.
    • Tan J, Wang QY, Feng GM, Li XY, Huang W. Increased Risk of Psychiatric Disorders in Women with Polycystic Ovary Syndrome in Southwest China. Chin Med J (Engl). 2017 Feb 5; 130(3): 262-266. doi: 10.4103/0366-6999.198916.
    • Tannus S, Burke YZ, Kol S. Treatment strategies for the infertile polycystic ovary syndrome patient. Womens Health (Lond). 2015 Nov; 11(6): 901-12. doi: 10.2217/whe.15.40.
    Publication of the article «World of Medicine and Biology» №4(66), 2018 year, 087-090 pages, index UDK 618.11-006+612.6
    DOI 10.26724/2079-8334-2018-4-66-87-90