R.I. Yatsyshyn, P.R. Herych, O.M. Didushko, O.A. Shapoval

PATHOGENETIC EFFECTS IN THE TREATMENT OF COMBINED CARDIORESPIRATORY PATHOLOGY

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About the author:	R.I. Yatsyshyn, P.R. Herych, O.M. Didushko, O.A. Shapoval
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	Study of the possibility to correct endothelial dysfunction (ED), structural changes in peripheral arteries and synthesis of metabolic-waste products of nitric oxide (NO) (nitrites NO_2^- / nitrates NO_3^-) by means of including the combination of roflumilast and quercetin to the background therapy has been investigated. In 6 months, the use of complex therapy, in contrast to the background one, has resulted in a statistically significant increase of the initial rate by 18.76% from (0.61 ± 0.04) m/s to (0.75 ± 0.04) m/s (t=2.47; p<0.05) and in a statistically significant decrease of the initial diameter of a brachial artery to 3.74 ± 0.28 mm (t=2.49; p<0.05). Administration of complex therapy after 6 months has showed that the concentration of NO metabolites in the blood has gone up 1.3 times, up to 10.35 ± 1.89 mcmole/l (t=1.00; p>0.1) with the norm of 12.05 ± 2.11 mcmole/l. Administration of complex therapy for patients with a severe stage of chronic obstructive pulmonary disease (COPD) in an exacerbation phase accompanied with a stable coronary artery disease and stable effort angina (SCAD SEA) of the 2nd FC helps restore endothelial function, improves peripheral arterial structural changes and has a stimulating effect on the synthesis of NO.
Tags	stable coronary artery disease, chronic obstructive pulmonary disease, endothelial dysfunction, oxidative stress
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Publication of the article	«World of Medicine and Biology» №1(67), 2019 year, 121-125 pages, index UDK 616-08+615.276+616.24+616.12-009.72
DOI	10.26724/2079-8334-2019-1-67-121