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    V.S. Shkolnikov, L.L. Zalevskiy, T.M. Kyselova, V.O. Gnenna


    About the author: V.S. Shkolnikov, L.L. Zalevskiy, T.M. Kyselova, V.O. Gnenna
    Type of article Scentific article
    Annotation The study was performed to establish the structure of the vermis and cerebellum hemispheres macrometric parameters, as well as morphometric parameters and cytoarchitectonics of the human cerebellum on the 13th-14th weeks of fetal development. The anatomic-histological, immunohistochemical and morphometric study was carried out on the vermis and hemispheres of the cerebellum in 12 human fetuses with a gestation term of 13-14 weeks without abnormalities of the central nervous system, which were obtained as a result of a late abortion in the regional pathologist bureau of Vinnytsia. The study found: the transverse size of the cerebellum, longitudinal dimensions, height and transverse size of the cerebellum right and left hemisphere; transverse, longitudinal size and height of the vermis, as well as mass of the cerebellum. It is established that in the histo-cytoarchitectonics of the cerebellum hemispheres, there are three layers: the ventricular zone, the intermediate zone, the cortical zone, which in turn is divided into internal granular, molecular and external granular layers. In the course of the research it was established: the ventricular zone of the right cerebellum has the smallest thickness, and the intermediate zone has the largest thickness; the intermediate zone of the left cerebellum has the greatest thickness, and the ventricular zone has the smallest thickness; the smallest density of neural stem cells is observed in the molecular zone, and the largest is in the ventricular zone; more intensive proliferation of neural stem cells present in the ventricular zone, and less intense - in the intermediate zone; starting from the ventricular zone, the radial glial cells fibers pass through all layers of the cerebellum to the external granular layer in the radial direction; the expression of Synaptophysin is present in all layers of the cerebellum. Thus, the macrometric parameters of the cerebellum formations of 13-14 weeks fetuses are established.
    Tags cerebellum vermis, cerebellum hemispheres, morphometric parameters, radial glia, intrauterine development
    • Shkolnikov VS, Zalevskiy LL, Stelmashchuk PO, Tikholaz VO. Sposib vyznachennya makrometrychnyx parametriv struktur mozochka. Patent u2016 07526 Ukrayina, MPK А61В 5/107. 2016; 8. [in Ukrainian]
    • Acton QA. Chromosome disorders – advances in research and treatment. 2012; Edition is a ScholarlyBabcook CJ, Chong BW, Salamat MS, Ellis WG, Goldstein RB. Sonographic anatomy of the developing cerebellum: normal embryology can resemble pathology. AJR Am. J. Roentgenol. 1996; 166(2): 427-433.
    • Guihard-Costa AM, Larroche JC. Differential growth between the fetal brain and its infratentorial part. Early Hum. Dev. 1990; 23(1): 27-40.
    • Kabbani H, Raghuveer TS. Craniosynostosis. Am. Fam. Physician. 2004; 69(12): 2863-2870.
    • Liu F, Zhang Z, Lin X, Teng G, Meng H, Yu T, Fang F, Zang F, Li Z, Liu S. Development of the human fetal cerebellum in the second trimester: a post mortem magnetic resonance imaging evaluation. J. Anat. 2011; 219(5): 582-588.
    • Loeser JD, Lemire RJ, Alvord EC. The development of the folia in the human cerebellar vermis. Anat. Rec. 1972; 173(1): 109-113.
    • Milosevic A, Zecevic N. Developmental changes in human cerebellum: Expression of intracellular calcium receptors, calcium-binding proteins, and phosphorylated and nonphosphorylated neurofilament protein. J. Comp. Neurol. 1998; 396(4): 442-460.
    • Volpe JJ. Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important. J. Child. Neurol. 2009; 24(9): 1085-1104.
    • Yamaguchi K, Goto N. Three-dimensional structure of the human cerebellar dentate nucleus: a computerized reconstruction study. Anat. Embryol. (Berl). 1997; 196(4): 343-348.
    Publication of the article «World of Medicine and Biology» №1(67), 2019 year, 203-208 pages, index UDK 616.831.71-053.13
    DOI 10.26724/2079-8334-2019-1-67-203