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    S.O. Zubchenko, V.V. Chopyak, A.M. Havrylyuk, G.O. Potemkina, M.P. Lomikovska


    About the author: S.O. Zubchenko, V.V. Chopyak, A.M. Havrylyuk, G.O. Potemkina, M.P. Lomikovska
    Type of article Scentific article
    Annotation Epstein-Barr (EBV) virus initiates a wide spectrum of immunomodulating effects in the human body. EBV is one of the first viruses, in which expression of miRNAs has been revealed, that are used as targets for detection of the virus in clinical investigations. To investigate association relationships of miR-BART 13 and 15 in patients with allergopathy and chronic EBV-infection in active and latent phases. In general, 46 patients with chronic EBV-infection in active/latent phases have been examined, age 18-59 years, 65% of females, 37% of males. Clinical, general laboratory, instrumental, specific allergological, molecular genetic, and cytological investigations were performed. High levels of miR-BART 13 expression were detected in patients with allergopathy in combination with chronic EBV-infection in active (р<0.01) and latent (р<0.05) phases compared to healthy individuals. The difference in miRNAs 13, 15 expression levels depending on the medium of virus replication was not found. Investigation of miRNAs 13, 15 in the groups, formed according to verified allergic diseases, showed that higher levels of miRNAs 13 were observed in the group of patients with bronchial asthma (BA) in combination with an active phase of EBV-infection (p<0.01). Reverse correlation between miR-BART-13 and FEV1 and direct correlation with levels of total IgE were also detected in this group of patients. Higher indices of miR-BART 15 were recorded in patients with BA and active EBV-infection compared to control group (p<0.05). In patients with BA and active phase of chronic EBV-infection, elevation of the levels of miR-BART-13 expression can be a biomarker of the severity of allergic inflammatory process due to amplification of bronchial obstruction level and formation of hyper-IgE syndrome.
    Tags Chronic Epstein-Barr viral infection, allergic diseases, miR-BART 13, miR-BART 15
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    Publication of the article «World of Medicine and Biology» №2(68), 2019 year, 054-060 pages, index UDK 616-056.3-02:[616.98:578.825.13]-07
    DOI 10.26724/2079-8334-2019-2-68-54-60