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    N.I. Tokarchuk, Y.V. Vyzhga, V.T. Tokarchuk

    ROLE OF THE FIBROTIC MARKERS FOR PYELONEPHRITIS IN INFANTS


    About the author: N.I. Tokarchuk, Y.V. Vyzhga, V.T. Tokarchuk
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The study was aimed at estimation of the transforming growth factor ß1 and monocytic chemo attractant protein type I in infants with pyelonephritis. Pyelonephritis against the background of vesicoureteral reflux is followed by high activity of the inflammatory process with increased amount of MCP-1 in serum that by 2.5 times exceeds the results of the kids with primary pyelonephritis. During the study we evaluated high results of the profibrotic marker TGF В1 against the background of vesicoureteral reflux in infants that is by 2.8 times higher than results of the kids with primary pyelonephritis. The article is dedicated to the study of fibrotic markers, polymorphic variants of gene TGF- ß1 in positions -509СТ and +869СТ in pyelonephritis against the background of vesicoueretral reflux in infants. Children that found to be a careers of genotype С-509С and Т+869Т gene of transforming growth factor В1 have more severe course of the disease and hyperproduction of serum TGF-B1 than heterozygote and homozygote Т-509Т and С+869С.
    Tags pyelonephritis, transforming growth factor В1, monocytic chemo attractive protein-1, gene polymorphism of transforming growth factor В1
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    Publication of the article «World of Medicine and Biology» №2(68), 2019 year, 121-126 pages, index UDK 616.61-002-053.3
    DOI 10.26724/2079-8334-2019-2-68-121-126