| About the author: |
Nefodova O.O., Shatorna V.F., Halperin O.I., Nefodov O.O., Yеroshenko G.A, Tverdokhlib I.V., Harets V.I. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the experimental study was to determine the impact of cadmium chloride on the overall course of cardiogenesis with intragastric administration throughout the entire pregnancy period in rats. Experimental studies were carried out on female Wistar rats. To simulate the effect of cadmium chloride throughout the pregnancy, Wistar female rats were daily administered the aqueous solution of cadmium chloride per os via a probe at the dose of 1.0 mg/kg. The cardiofetal index growing in the group of exposure to cadmium chloride indicates an increase in the cardiac weight in the group when the embryo body weight is reduced due to intoxication. Microscopically, in 12.3% of rats the atrium endocardium hyperplasia was detected in the group exposed to cadmium chloride at the indicated dose. In 26-29% of rats cadmium chloride also led to changes in the formation of the embryo heart ventricles wall: thickening of both the compact and trabecular myocardium layers and the formation of abnormal forms of trabeculas. |
| Tags |
cardiogenesis, myocardium, heart ventricle, atrium, cadmium |
| Bibliography |
- Skalnyy AV, Zaytseva IP, Tinkov AA. Mikroelementy i sport. Personalizirovannaya korrektsiya elementnogo statusa sportsmenov. M.: Sport; 2018. 288 s. [in Russiаn]
- Slyuzova OV, Stepanova YEV, Bucharskaya AB. Razvitiye adaptatsionnykh mekhanizmov u samok belakh krys v otvet na vozdeystviye ionov kadmiya. Toksikologicheskiy vestnik. 2008; 3: 23–27. [in Russiаn]
- Oberlis D, Skalnyi AV, Skalnaya MG. Patofiziologiya mikroelementozov. Patogenez. 2016; 14(2): 20-27. [in Russian]
- Fomenko OZ, Shaulskaya OE, Kot YG, Ushakova GA, Shevtsova AI. Vliyaniye raznykh doz kadmiya na aktivnost matriksnykh metalloproteinaz v serdtse, mozge i syvorotke krovi krys. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2016; 3: 103-7. [in Russian]
- Frolova NA, Mirzoyev EB., Kobyalko VO., Gubina OA. Otvetnaya reaktsiya organizma krys pri khronicheskom vozdeystvii kadmiya v antenatal'nyy i molochnyy period vskarmlivaniya. Aktualnyye problemy ekologii i prirodopol'zovaniya. Sbornik nauchnykh trudov. - M.: IPTS "Luch". 2010; 12: 226-230. [in Russian]
- Shatorna VF, Haretsʹ VI, Kononova II. Porivnyannya efektiv vplyvu soley svyntsyu ta kadmiyu na embriohenez u shchuriv. Ukrayinskyi zhurnal medytsyny, biolohiyi ta sportu. 2018; T. 3, 6(15): S.310-314. [in Ukrainian]
- Shchorichna dopovid pro stan zdorovya naselennya, sanitarno-epidemichnu sytuatsiyu ta rezultaty diyalnosti systemy okhorony zdorovya Ukrayiny. 2016 rik. MOZ Ukrayiny, DU «UISD MOZ Ukrayiny». Kyiv; 2017. 516 s. [in Ukrainian]
- Gidding SS. Cardiovascular risk factors in adolescents. Curr. Treat. Options Cardiovasc. Med. 2006; 8 (4): 269275.
- Dourson M, Becker RA., Haber LT, Pottenger L H., Bredfeldt T, Fenner-Crisp PA. Advancing human health risk assessment: Integrating recent advisory committee recommendations // Critical Reviews in Toxicology. 2013 Jul; 43(6): 467–492.
- Järup L, Åkesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol [Internet]. 2009 [cited 2018 July 17];238(3):201-8.
|
| Publication of the article |
«World of Medicine and Biology» №3(69), 2019 year, 209-213 pages, index UDK 611.12-076:611.013:616-092.9:669.018.674 |
| DOI |
10.26724/2079-8334-2019-3-69-209-213 |
