| About the author: |
Lukyantseva H.V., Pastukhova V.A., Kovalchuk A.I., Dutchak U.M. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Long-term administration of yellow tartrazine (E102) stain to sexually mature white rats at doses of 750 mg/kg and 1500 mg/kg is accompanied by a significant dose-dependent disorder in the chemical composition of bones, namely, it leads to a significant decrease in the content of organic and mineral substances, an increase in the number of hydrophilic elements with simultaneous bone tissue overhydration. The combined use of selenase, pharmacological antioxidant action corrector, with tartrazine significantly increased bone mineralization, led to an increase in the organic and mineral substances content, and also reduced the degree of bone overhydration caused by an increase in the content of sodium and potassium under the effect of E102. |
| Tags |
tartrazine, bones, chemical composition, selenase |
| Bibliography |
- Bіlyk AL. Osoblivostі struktury ta khіmіchnoho skladu plechovykh kіstok u bіlykh laboratornykh shchurіv-samtsіv z rіznym typom avtonomnoho vіddіlu nervovoyi systemy. Zdobutky klіnіchnoyi ta eksperymentalnoyi medytsyny. 2007; 2:33-6. [in Ukrainian]
- Britske EM. Atomno-absorbtsionnyi spektralnyi analiz. M.: Khimiya; 1982. 244 s. [in Russian]
- Kolb VN, Kamyshnikov VS. Klinicheskaya biokhimiya. Minsk: Belarus; 1976. 211 s. [in Russian]
- Luzin VI, Lubenets AA, Strii VV. Fazovyi sostav mineralov tazovoy kosti pri implantatsii v bolshebertsovuyu kost biogennogo gidroksilapatita. Travma. 2009; 10(2):216-20. [in Russian]
- Pastukhova VA, Grishchuk MG. Izmenenie ultrastruktury mineralov kosti i dentina reztsa nizhney cheliusti u belykh krys posle vozdeystviya ekstremalnoy khronicheskoy gipertermii. Vіsnyk problem bіolohiyi і medytsyny. 2014; 2(2):80-8. [in Russian]
- Pogorelov MV, Bumeister VІ, Tkach GF, Bonchev SD, Sukhodub LF, Danilchenko SM. Makro- ta mіkroelementy (obmіn, patolohiya ta metody viznachennia). Sumy: Vid-vo SumDU; 2010. 147 s. [in Ukrainian]
- Tkach GF, Bushtruk AM, Pogorelov MV, Markevich OV. Dinamіka rostovykh pokaznykіv ta khіmіchnoho skladu kіstok v postnatalnomu ontogenezі. Tavricheskiy mediko-biologicheskiy vestnik. 2012; 15(4):355-9. [in Ukrainian]
- Amin KA, Abdel Hameid H, Abd Elsttar AH. Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food Chem Toxicol. 2010; 48(10):2994-99.
- European convention for the protection of vertebrate animals used for experimental and other scientific purpose: Council of Europe 18.03.1986. Strasbourg; 1986. 52 p.
- Kashanian S, Zeidali S. DNA binding studies of tartrazine food additive. DNA Cell Biol. 2011; 30(7):499-505.
- Mohamed AA, Gadal AA, Elewa YH. Comparative protective effects of royal jelly and cod liver oil against neurotoxic impact of tartrazine on male rat brain. Acta Histochem. 2015; 117(7):649-58.
- Mpountoukas P, Pantazaki A, Kostareli E. Cytogenetic evaluation and DNA interaction studies of the food colorants amaranth, erythrosine and tartrazine. Food Chem Toxicol. 2010; 48(10):2934-44.
- Pestana S, Moreira M, Olej B. Safety of ingestion of yellow tartrazine by double-blind placebo controlled challenge in 26 atopic adults. Allergol Immunopathol (Madr). 2010; 38(3):142-6.
- Raposa B, Szíjártó G, Bereniy K. A brief review of health effects of tartrazine (Е 102). Journal of Proactive Medicine. 2012; 1(2):53-6.
- Soares BM, Araújo TM, Ramos JA, Pinto LC, Khayat BM, De Oliveira Bahia M, et al. Effects on DNA repair in human lymphocytes exposed to the food dye tartrazine yellow. Ramos Anticancer Res. 2015; 35(3):1465-74.
|
| Publication of the article |
«World of Medicine and Biology» №4(70), 2019 year, 203-208 pages, index UDK 599.23:611.717.1+547.476.3 |
| DOI |
10.26724/2079-8334-2019-4-70-203-208 |
