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    Rodionova V.V., Karasova O.V., Bekh O.E., Tkachenko V.A., Gordiienko Iu.A.


    About the author: Rodionova V.V., Karasova O.V., Bekh O.E., Tkachenko V.A., Gordiienko Iu.A.
    Type of article Scentific article
    Annotation Idiopathic pulmonary fibrosis is a severe, steadily progressive disease. Lack of specific signs and presence of individual variations in the course of the disease indicate the need to find additional non-invasive markers for diagnosis, estimation of the disease severity and monitoring of treatment effectiveness. Therefore, this study aimed to determine activities of gelatinase A and gelatinase B activities, as well as progelatinase B/lipocalin complex in patients with moderate and severe IPF. It was found that increased gelatinase A and gelatinase B activities correlated with the disease progression. Increased activities of progelatinase B and its active form at different stages of the disease can be used as markers of the severity of the fibrotic process, while gelatinase A activity can indicate its stage. Changes in the progelatinase B/lipocalin complex activity reflect clinical signs and symptoms during the idiopathic pulmonary fibrosis course and are associated with the severity of the disease.
    Tags idiopathic pulmonary fibrosis, gelatinases A and B, progelatinase B/lipocalin complex
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    Publication of the article «World of Medicine and Biology» №3(73), 2020 year, 091-096 pages, index UDK 616.24-002.17-021.3-036-074
    DOI 10.26724/2079-8334-2020-3-73-91-96