| About the author: |
Tiron O.I., Appelhans O.L., Gunas V.I., Chereshniuk I.L., Lysenko D.A. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The DNA content in the nuclei of thyroid cells of 90 white male rats on the background of skin burns of 2-3 degrees (with a lesion area of 21-23 % of the body surface) and the introduction of solutions of lactoprotein with sorbitol or HAES-LX 5 % was determined by flow cytometry. At 1, 3, 7 and 14 days after thermal trauma to the skin and the use of lactoprotein with sorbitol or HAES-LX 5 %, only lower values of S-phase values were found compared to the groups without burns. 21 days after thermal damage to the skin in the group with infusion HAES-LX 5 %, the interval SUB-G0G1 is significantly higher than in the control group. After 30 days in the groups with prior administration of HAES-LX 5 % and lactoprotein with sorbitol solutions, the value of SUB-G0G1 is significantly higher than that in the groups without skin burns. |
| Tags |
thyroid gland, thermal skin burn, DNA cytometry, HAES-LX 5 %, lactoprotein with sorbitol |
| Bibliography |
- Pavlov AV, Bezdenezhny`kh AV. Proliferativnaya i sekretornaya aktivnost follikulyarnykh tiroczitov pri razlichny`kh rezhimakh myshechnoy deyatelnosti. Vestnik novykh meditsinskikh tekhnologiy. 2018;25(3):202-8. [in Russian]
- Batista G, Hensch TK. Critical period regulation by thyroid hormones: potential mechanisms and sex-specific aspects. Frontiers in molecular neuroscience. 2019; 12:77. https://doi.org/10.3389/fnmol.2019.00077
- Cherkasov VG, Dzevulska ІV, Cherkasov EV, Kaminsky RF, PastukhovaVA, Kovalchuk OІ, Trofimenko YuYu. Influence of HAES-LX-5% infusion solution on the DNA content of endocrine glands cells against the background of thermal burn of skin in rats. World of Medicine and Biology. 2017;4(62):168-73. DOI: 10.26724/2079-8334-2017-4-62-168-173
- D’Asta F, Cianferotti L, Bhandari S, Sprini D, Rini GB, Brandi ML. The endocrine response to severe burn trauma. Expert review of endocrinology & metabolism. 2014;9(1):45-59. https://doi.org/10.1586/17446651.2014.868773
- Gillenwater J, Garner W. Acute Fluid Management of Large Burns: Pathophysiology, Monitoring, and Resuscitation. Clinics in plastic surgery. 2017;44(3):495-503. https://doi.org/10.1016/j.cps.2017.02.008
- Gunas I, Dovgan I, Masur O. Method of thermal burn trauma correction by means of cryoinfluence. Jena–München: Der Urban & Fischer Verlag; 1997. 105.
- Mason SA, NathensAB, Byrne JP. Increased rate of long-term mortality among burn survivors: A population-based matched cohort study. Annals of surgery. 2019;269(6):1192-9. doi: 10.1097/SLA.0000000000002722
- Oryan A, Alemzadeh E, Moshiri A. Burn wound healing: present concepts, treatment strategies and future directions. Journal of wound care. 2017;26(1);5-19. https://doi.org/10.12968/jowc.2017.26.1.5
- Porter C, Tompkins RG, Finnerty CC, Sidossis LS, Suman OE, Herndon DN. The metabolic stress response to burn trauma: current understanding and therapies. The Lancet. 2016;388(10052):1417-26. https://doi.org/10.1016/S0140-6736(16)31469-6
- Rae L, Fidler P, Gibran N. The physiologic basis of burn shock and the need for aggressive fluid resuscitation. Critical care clinics. 2016;32(4):491-505. https://doi.org/10.1016/j.ccc.2016.06.001
- Stanojcic M, Abdullahi A, Rehou S, Parousis A, Jeschke MG. Pathophysiological response to burn injury in adults. Annals of surgery. 2018;267(3):576-84. doi: 10.1097/SLA.0000000000002097
- Tiron OI, Appelhans OL, Gunas IV, ChereshniukIL. Indicators of the cell cycle in the thyroid gland in rats when applying infusion of 0.9 % solution of NaCl, lactoprotein with sorbitol or HAES-LX 5 %. Reports of Morphology. 2019;25(1):62-7. https://doi.org/10.31393/morphology-journal-2019-25(1)-09
- Tiron OI. Indicators of the cell cycle in the thyroid gland in rats when using infusion of 0.9 % NaCl solution on the background of thermal skin burns. Reports of Morphology. 2019;25(3):52-7. https://doi.org/10.31393/morphology-journal-2019-25(3)-09
- Williams FN, Herndon DN. Metabolic and endocrine considerations after burn injury. Clinics in plastic surgery. 2017;44(3):541-53. https://doi.org/10.1016/j.cps.2017.02.013
|
| Publication of the article |
«World of Medicine and Biology» №3(73), 2020 year, 225-230 pages, index UDK 616.441:572.7 |
| DOI |
10.26724/2079-8334-2020-3-73-225-230 |
