| About the author: |
A. O. Mykytenko, O. Ye. Akimov, G. A. Yeroshenko |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The article deals with the peculiarities of connective tissue degradation in rat liver on early terms of chronic alcoholic hepatitis modelling. Modeling of chronic alcoholic hepatitis leads to the development of oxidative stress in rat liver tissues due to a decrease in the activity of antioxidant enzymes and an increase in the production of reactive oxygen species. As a result of the development of oxidative stress in the liver of rats in the first stages of modeling alcoholic hepatitis, the concentration of the anti-inflammatory heparin-heparan fraction of glycosaminoglycans decreases, the accumulation of keratan-dermatan and chondroitin fractions of glycosaminoglycans occurs. The processes of degradation of the fibrous components of the liver’s connective tissue increase and the concentration of the sulfide anion decreases. |
| Tags |
rats, alcoholic hepatitis, connective tissue, sulfide anion, glycosaminoglycans, L-hydroxyproline |
| Bibliography |
- Kaidashev IP. Metody klinichnykh ta eksperymentalnykh doslidzhen u medytsyni. Poltava: Polimet, 2003. 319 p. [In Ukrainian].
- Stepanov YuM, Didenko VI, Dynnik OB, Konenko IS, Oshmianskaia NYu, Galinsky AA. Asotsiatsiya morfolohichnykh zmin parenkhimy pechinky ta yiyi ryhidnist v umovakh eksperymentalnoho modelyuvannya alkoholnoho ta toksychnoho hepatytu. Journal of the NAMSU. 2017; 23 (3-4): 196-204. [In Ukrainian].
- Akimov OYe, Mischenko AV, Kostenko VO. Influence of combined nitrate and fluoride intoxication on connective tissue disorders in rats gastric mucosa. Archives of the Balkan Medical Union. 2019; 54(3):11-15. doi. 10.31688/ABMU.2019.54.3.03.
- Alyoussef A, Taha M. Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2. Exp Dermatol. 2019; 28(1): 28-34. doi: 10.1111/exd.13802.
- Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O et al. Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis. PLoS One. 2020; 15(7): e0235990. doi: 10.1371/journal.pone.0235990.
- Faria-Ramos I, Poças J, Marques C, Santos-Antunes J, Macedo G, Reis CA et al. Heparan Sulfate Glycosaminoglycans: (Un)Expected Allies in Cancer Clinical Management. Biomolecules. 2021; 11(2): 136. doi: 10.3390/biom11020136.
- Gérard-Monnier D, Erdelmeier I, Régnard K, Moze-Henry N, Yadan JC, Chaudière J. Reactions of 1-Methyl-2-phenylindole with Malondialdehyde and 4-Hydroxyalkenals. Analytical Applications to a Colorimetric Assay of Lipid Peroxidation, Chem. Res. Toxicol. 11(10) (1998) 1176-83.
- Hong S, Kim Y, Sung J, Lee H, Heo H, Jeong HS et al. Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation. Evid Based Complement Alternat Med. 2020; 2020: 6684331. doi: 10.1155/2020/6684331.
- Read E, Zhu J, Yang G. Disrupted H2S Signaling by Cigarette Smoking and Alcohol Drinking: Evidence from Cellular, Animal, and Clinical Studies. Antioxidants (Basel). 2021 Jan 3; 10(1):49. doi: 10.3390/antiox10010049.
- Reynolds-Peterson C, Xu J, Zhao N, Cruse C, Yonel B, Trasorras C et al. Heparan Sulfate Structure Affects Autophagy, Lifespan, Responses to Oxidative Stress, and Cell Degeneration in Drosophila parkin Mutants. G3 (Bethesda). 2020 Jan 7; 10(1):129-141. doi: 10.1534/g3.119.400730.
- Staitieh BS, Egea EE, Fan X, Amah A, Guidot DM. Chronic Alcohol Ingestion Impairs Rat Alveolar Macrophage Phagocytosis via Disruption of RAGE Signaling. Am J Med Sci. 2018; 355(5): 497-505. doi: 10.1016/j.amjms.2017.12.013.
- Sugahara S, Suzuki M, Kamiya H, Yamamuro M, Semura H, Senga Y, Egawa M, Seike Y. Colorimetric Determination of Sulfide in Microsamples. Anal Sci. 2016; 32(10): 1129-1131. doi: 10.2116/analsci.32.1129.
- Teschke R. Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects. Biomedicines. 2018; 6(4): 106. doi: 10.3390/biomedicines6040106.
- Wu J, Yang F, Zhang X, Chen G, Zou J, Yin L et al. Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress. Int J Mol Med. 2021 Apr; 47(4):34. doi: 10.3892/ijmm.2021.4867.
- Zhang W, Rho JH, Roehrl MH, Wang JY. A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins. BMC Immunol. 2019 Jun 26; 20(1):21. doi: 10.1186/s12865-019-0304-1.
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| Publication of the article |
«World of Medicine and Biology» №1(75), 2021 year, 197-200 pages, index UDK 616.36-002:599.323.4 |
| DOI |
10.26724/2079-8334-2021-1-75-197-200 |
