| About the author: |
A. G. Kornatska, М. А. Flaksemberg, G. V. Chubei, О. V. Trokhymovych, L. Ye. Fishchuk, N. L. Medvedieva, Z. I. Rossokha |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of this study was to investigate the effect of ESR1, PGR genes variants and hypermethylation of promoter region of the ESR1 gene on the risk of uterine leiomyoma in women. The risk of disease development was associated with ESR1 genes variants, and in the presence of 397CC genotype of the ESR1 gene were observed significantly larger size of the dominant node and early onset of the disease in patients. PGR gene variant modified the risk of uterine leiomyoma development. The T1/T2 heterozygous variant of the gene was associated with a reduced risk of uterine leiomyoma development in women. In the presence of the T1/T1 gene variant, the risk of uterine leiomyoma development was significantly 2.5-time increased, and was significantly 4-time increased for patients with this genotype in combination with 351AA genotype of the ESR1 gene. Hypermethylation of the ESR1 gene promoter region was an additional risk factor for uterine leiomyoma development and was detected in patients with unsuccess treatments response. |
| Tags |
genetic risk, ESR1, PGR, methylation, uterine leiomyoma |
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| Publication of the article |
«World of Medicine and Biology» №2(76), 2021 year, 058-063 pages, index UDK 575.191:618.14-006.363.03-056.7-092.12 |
| DOI |
10.26724/2079-8334-2021-2-76-58-63 |
