| About the author: |
V. P. Mishchenko, I. V. Rudenko, V. K. Likhachov, A. M. Gromova, K. V. Tarasenko |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
120 women of reproductive age were examined. Alleles of folate-related enzyme genes, the content of folic acid, cyanocobalamin, vitamins B1, B6 in the blood were determined. Prevention of miscarriage was based on preconception training of men and women (spouses). The pre-conceptual examination plan included a thorough study of the anamnesis, including family history; laboratory determination of folic acid, vitamins B12, B1, B6 in the blood of future parents (both woman and man). Decreased vitamin content or their level at the lower limit of normal was an indication for determining the folate-related enzyme genes (MTHFR: 1298A/C; 677C/T, MTR: 2756A/G, MTRR: 66A/G). Given the high (78.1 %) incidence of carriers of “functionally attenuated” (polymorphic) genes of folate cycle enzymes, both expectant parents were prescribed modern complexes of vitamins, microelements and amino acids containing Metafolin at the stage of preconception preparation 3-4 months before fertilization and during pregnancy according to the trimesters of gestation. Clinical and laboratory approach to the correction of vitamins, macro-, microelements, amino acids based on laboratory assessment of hereditary impairment of specific enzymes and by prescribing personalized therapy had a positive result in 57 (95.0 %) patients, which confirms its effectiveness. |
| Tags |
folic acid, vitamins B12, B1, B6, alleles of folate-related enzyme genes, prevention of miscarriage |
| Bibliography |
- Antipkin YG, Davydova ОI. Osnovnyye napravleniya razvitiya perinatalnoy meditsiny Reproduktvna endokrinolohiya. 2012; 2, 4, 5–7. [in Russian]
- Baranov VS. Evolyutsiya prediktivnoy meditsiny. Staryye idei, novyye ponyatiya. Meditsinskaya genetika. 2017; 16, 5, 4–9 [in Russian]
- Bitsadze VO, Samburova NV, Makatsariya NA, Mishchenko AL. Folatdefitsitnyye sostoyaniya v akusherskoy praktike i problema ikh korrektsii Akusherstvo, ginekologiya i reproduktsiya. 2016; 10, 1, 38–48; doi 10.17749/2313 – 7347.2015.10.1.038–048. [in Russian]
- Ventskovskiy BM, Zagorodnyaya AS, Leush SSt. Polimorfizm genov folatnogo obmena kak prichina prezhdevremennykh rodov Reproduktivnoye zdorovye. Vostochnaya Yevropa, 2015; 4, 8–15; doi: 10.1016/j.bpobgyn.2020.09.002. Epub 2020 Sep 8. [in Russian]
- Gorbunova OV, Rukomeda NV. Profílaktika nevynoshuvannya vagitnosti ta perinatalnoyi patologiyi u zhinok z leyomiomoyu matky. Health of woman, 2015; 1, 97, 49-51; doi 10.15574/HW.2015.97.49. [in Ukrainian]
- Kan NYe, Khachatryan ZV, Tyutyunik VL, Lomova NA, Donnikov AYe. Primeneniye folatrov v profilaktike zaderzhki rosta ploda pri beremennosti. Meditsinskiy sovet. 2018; 13, 65–67; doi 10.21518/2079–701kh–2018–13–65–67. [in Russian]
- Mishchenko VP, Rudenko IV, Zaporozhchenko MB, Lavrinenko GL. Osoblyvosti pregravidarnoyi pidgotovky zhinok riznykh natsionalnostey Aktualní pytannya pediatriyi, akusherstva tahinekolohiyi. 2017; 1, 19, 105–110; doi 10.11603/2416–4944.2017.1.7292. http://nbuv.gov.ua UJRN/appatg 017_1_24. [in Ukrainian]
- Rudenko, IV, Mishchenko, VP Patogenetichne obgruntuvannya personifikovanoyi korektsiyi porushen folatnogo tsiklu za dopomogoyu kompleksu z metafolinom dlya profilaktyky vrodzhenykh vad rozvytku. Reproduktyvna endokrinolohiya, 2020; 2, 52, 67–72. [in Ukrainian]
- Khilkevich YeG, Yazykova OI. Aktivnyye folaty so stoprotsentnym usvoyeniyem Meditsinskiy sovet.2017; 2, 48–50; doi 10.21518/2079–701kh–2017–2–– 48–50. [in Russian].
- Czeizel AE, Dudas Í, Vereczkey A. Folate deficiency and folic acid supplementation: the prevention of neural– tube defects and congenital heart defects. Heart Defects Nutrients. 2013; 5, 11, 4760–4775.í
- Devall AJ, Coomarasamy, A. Sporadic pregnancy loss and recurrent miscarriage. Best Practice & Research: Clinical Obstetrics & Gynaecology. 2020; 69, 30–39; doi: 10.1016/j.bpobgyn.2020.09.002. Epub 2020 Sep 8.
- Engel SM, Olshan, AR, Siega–Riz AM. Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small for gestational age birth. Am. J. Obstet.Gynecol. 2006; 195(5):1231.
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| Publication of the article |
«World of Medicine and Biology» №2(76), 2021 year, 093-098 pages, index UDK 618.396-085.356:577.164.17-084 |
| DOI |
10.26724/2079-8334-2021-2-76-93-98 |
