| About the author: |
A. O. Ponyrko, S. M. Dmytruk, V. I. Bumeister |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The pathomorphological basis for the development of diabetic disorders in various bones is a relevant subject of modern experimental research on the modeling of diabetes–associated destructive processes in the skeletal system. They are characterized by reduced bone density, which leads to an increased risk of fractures. Bone strength mainly depends on the interaction and concentration of chemical elements such as Ca, P, Mg, and K. Therefore, the purpose of our study was to determine the interdependence of changes in biomechanical parameters depending on the concentration of chemical elements in long tubular bones of rats under chronic hyperglycemia. The study was performed on 72 adult white laboratory rats lasting 180 days. It was found that starting from 30 days of uncontrolled chronic hyperglycemia, the bone mineral density in rats of the experimental group gradually decreased in comparison with the dynamics of the corresponding indexs in animals of the control group. These changes were accompanied by pronounced demineralization of both bones, as evidenced by significant losses of macronutrients (Ca, P, Mg and K). As a result, in chronic hyperglycemia gradually formed a complex violation of the structure and biomechanical properties of long tubular bones, which is a pathomorphological basis in the corresponding loci of the skeletal system. |
| Tags |
rats, hyperglycemia, tubular bones, bone mineral density, macronutrient bone composition |
| Bibliography |
- Abdulrahman N, McComb C, Foster JE. Deficits in trabecular bone microarchitecture in young women with type 1 diabetes mellitus. Journal of Bone and Mineral Research. 2015; 30(8): 1386–1393. Doi: 10.1002/jbmr.2465.
- Bonora E, DeFronzo RA. Diabetes complications, comorbidities and related disorders. Cham: Springer Nature Switzerland. 2020; 724. Doi: 10.1007/978–3–030–36694–0.
- Burr D, Allen M. Basic and Applied Bone Biology. Academic Press.2019; 2nd Edition: 454 s.
- Carvalho FR, Calado SM, Silva GA, Diogo GS, Moreira da Silva J, Reis RL et al. Altered bone microarchitecture in a type 1 diabetes mouse model Ins2Akita. J Cell Physiol. 2019; 234 (6): 9338–9350. Doi: 10.1002/jcp.27617.
- de Mello–Sampayo C, Agripino AA, Stilwell D, Vidal B, Fernando AL, Silva – Lima B et al. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. Int. J Endocrinal.2017; 2017: 4603247. Doi: 10.1155/2017/4603247.
- de Oliveira GJPL, Basso TLD, Fontanari LA, Faloni APS, Júnior ÉM, Orrico SRP. Glycemic control protects against trabecular bone micro–architectural damage in a juvenile male rat model of streptozotocin-induced diabetes. Endocrine Research.2017; 42 (3). doi.org/10.1080/07435800.
- Jiao H, Xiao E, Graves DT. Diabetes and Its Effect on Bone and Fracture Healing. Curr Osteoporosis Rep.2015; 13 (5): 327–35. Doi: 10.1007/s1191401502868.
- Joshi A, Varthakavi P, Chadha M, Bhagwat N. A study of bone mineral density and its determinants in type 1 diabetes mellitus. J Osteoporosis. 2013; 2013: 397–814. Doi: 10.1155/2013/397814.
- Kanazawa I. Interaction between bone and glucose metabolism [Review]. Endocrinology J. 2017; Nov 29; 64 (11): 1043–1053. Doi: 10.1507 / endocrj.EJ17–0323.
- Ohta T, Kimura S, Hirata M, Yamada T, Sugiyama T. Bone morphological analyzes in Spontaneously Diabetic Torii (SDT) fatty rats. J. Vet. Med. Sci.2015; 77 (10): 1330. doi: 10.1292/jvms.15–0154.
- Rendina-Ruedy E, Graef JL, Davis MR, Hembree KD, Gimble JM, Clarke SL et al. Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance. J Bone Miner Metab. 2016; 34 (4): 380–94. Doi: 10.1007 / s007740150685z.
- Schacter GI, Leslie WD. Diabetes and Bone Disease. Endocrinologist Metab Clin N Am. 2017; 46 (1): 63–85. Doi.org/10.1016/j.ecl.2016.09.010
- Shah VN, Carpenter RD, Ferguson VL, Schwartz AV. Bone health in type 1 diabetes. Curr Opin Endocrinology Diabetes Obes. 2018; 25 (4): 231–236. Doi: 10.1097/MED.0000000000000421.
- Zhang J, Chen X, Chen B, Tong L, Zhang Y. Tetrahydroxy stilbene glucoside protected against diabetes-induced osteoporosis in mice with streptozotocin-induced hyperglycemia. Phytotherapy Research. 2018; 33.1–10. Doi: 10.1002 / ptr.6240.
- Zhukouskaya VV, Eller-Vainicher C, Shepelkevich AP, Dydyshko Y, Cairoli E, Chiodini I. Bone health in type 1 diabetes: focus on evaluation and treatment in clinical practice. J Endocrinology Invest. 2015; 38 (9): 941–50. Doi: 10.1007/s40618–015–0284–9.
|
| Publication of the article |
«World of Medicine and Biology» №2(76), 2021 year, 232-238 pages, index UDK 616.379–008.64:616.71–091–092.9 |
| DOI |
10.26724/2079-8334-2021-2-76-232-238 |
