English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    А. І. Yachmin, G. A.Yeroshenko, K. V. Shevchenko, S. M. Bilash, O. D. Lysachenko, V. M. Sokolenko, N. M. Sharlai, O. V. Klepets

    REMODELING OF THE GASTRIC FUNDIC VASCULATURE UNDER THE EFFECT OF COMPLEX OF MONOSODIUM GLUTAMATE, SODIUM NITRITE AND PONCEAU 4R


    About the author: А. І. Yachmin, G. A.Yeroshenko, K. V. Shevchenko, S. M. Bilash, O. D. Lysachenko, V. M. Sokolenko, N. M. Sharlai, O. V. Klepets
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The paper presents the data of morphometric study of the effect of the food additives complex on the state of the vasculature of the stomach fundus under the action of the complex of monosodium glutamate, sodium nitrite and Ponceau 4R food additives. It was found that in the early stages of the experiment there was spasm of blood vessels of the hemomicrocirculatory bed due to the direct effect of food additives on the mucous membrane, which led to increased diameters of submucosal vessels as a result of hemodynamic conditions of the mucous membrane. Further development of the inflammatory reaction and the phenomenon of hypoxia led to compensatory-restorative reactions, but complete recovery did not occur, which at the end of the experiment was expressed by decompensation of the resistive link, metabolic spasm and increased lumen of the capacitive link.
    Tags fundus of stomach, vessels, food supplements, mucous membrane, rats
    Bibliography
    • Lapach SN, Chubenko AV, Babych PN. Statisticheskiye metody v mediko-biologicheskikh issledovanyiakh s ispolzovanyem Exel. Kyev: Moryon. 2000; 320 s. [in Russian].
    • Makarova M, Rybakova A, Huschin Ya, Shedko V, Muzhykian A, Makarov V. Anatomo-fiziologicheskaya kharakteristika pishchevaritelnogo trakta u cheloveka i laboratornykh zhivotnykh. Mezhdunarodnyi vestnik veterenarii. 2016; 1: 82-104. [in Russian].
    • Beyreuther K, Biesalski HK, Fernstrom JD, Grimm P, Hammes WP, Heinemann U, et al. Consensus meeting: monosodium glutamate - an update. European Journal of Clinical Nutrition, 2017; 61(3): 304–313.
    • European Food Safety Authority. EFSA Panel on Food Additives and Nutrient Sources added to Food; Scientific Opinion on the reevaluation of Ponceau 4R (E 124) as a food additive onrequest from the European Commission. EFSA Journal 2009; 7(11):1328. [39 pp.].
    • European Food Safety Authority. Refined exposure assessment for Ponceau 4R (E 124). EFSA Journal. 2015 Apr 21;13(4). DOI:10.2903/j.efsa.2015.4073.
    • Johnson Leonard R. Gastrointestinal physiology. 9th edition. US, Philadelphia, PA: Elsevier; 2019. 155 p.
    • Leo L, Loong C, Ho XL, Raman MFB, Suan MYT, Loke WM. Occurrence of azo food dyes and their effects on cellular inflammatory responses.  Nutrition. 2018 Feb; 46: 36–40.
    • Motarjemi Y, Moy Ge, Todd E. Encyclopedia of Food Safety. 1st Edition, Motarjemi Y, chief editor. Elsevier Inc; Academic Press; 2013. 2304 р.
    • Oplatowska-Stachowiak M, Elliott CT. Food colors: Existing and emerging food safety concerns. Critical Reviews in Food Science and Nutrition. 2017; 57(3): 524–548. DOI: 10.1080/10408398.2014.889652.
    • Pronina OM, Koptev MM, SM Bilash SM, Yeroshenko GA. Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data. World of Medicine and Biology. 2018; 1(63): 153–57. DOI 10.26.724/2079-8334-2018-1-63-153-157.
    • Shevchenko KV, Yeroshenko GA, Yakushko OS, Kazakova KS, Kramarenko DR. Morphometric description of the exchange segment of microvasculature of rats’ salivary glands in normal conditions and chronic ethanol intoxication. Wiadomości Lekarskie. 2019; 72(3): 323–26. DOI 10.26.724/2079-8334-2020-1-71-232-235.
    • World Health Organization, International Agency for research on cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 94. Ingested Nitrate and Nitrite, and Cyanobacterial Peptide Toxins. Lyon, France; 2010. 464 p.;
    • Yachmin AI, Kononov BS, Yeroshenko GA, Bilash SM, Bilash VP. Ameasure of the effect of complex food additives on rats’adaptive responses. World of Medicine and Biology. 2020; 1(71): 232–235.
    • Yamjala K, Nainar MS, Ramisetti NR. Methods for the analysis of azo dyes employed in food industry--A review.  Food Chem. 2016 Feb 1; 192: 813-24. DOI: 10.1016/j.foodchem.2015.07.085.
    • Zanfirescu A, Ungurianu A, Tsatsakis AM, Nițulescu GM, Kouretas D, Veskoukis A, et al. A review of the alleged health hazards of monosodium glutamate. Compr Rev Food Sci Food Saf. 2019 Jul;18(4):1111–1134. DOI:10.1111/1541-4337.12448.
    Publication of the article «World of Medicine and Biology» №4(78), 2021 year, 255-261 pages, index UDK 616.33:615.24:599.323.41
    DOI 10.26724/2079-8334-2021-4-78-255-261