| About the author: |
S. O. Ostafiichuk, P. M. Prudnikov, P. R. Volosovskiy, N. I. Henyk |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
During pregnancy, the changes in carbohydrate and lipid metabolisms are determined by the level of gestational weight gain independent of the prepregnancy weight. In excessive weight gain women’s insulin concentration and insulin resistance index in the third trimester were higher compared to the early terms (p<0.05), while the insulin resistance index 1.8–fold (p<0.05) exceeded the similar index with normal gestational weight gain. There were hyperlipoproteinemia (p<0.05) in the second trimester and increased dyslipidemia in late pregnancy. The level of triglycerides at the end of pregnancy in 1.4–fold (p<0.05) exceeded this indicator with the recommended gestational weight gain patients. A significant association between the high levels of atherogenic lipids in the middle of pregnancy and an excessive increase in the percentage of body fat mass in late terms was found. Consequently, excessive gestational weight gain can be considered as the marker of disruption of adaptive metabolic changes in conditions of increased energy demand, with the risk of weight retention, development of obesity and metabolic syndrome after delivery. |
| Tags |
pregnancy, weight gain, insulin, lipids |
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| Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 113-117 pages, index UDK 618.3-06:612.015.32:612.397 |
| DOI |
10.26724/2079-8334-2022-1-79-113-117 |
