| About the author: |
V. M. Koka, I. I. Starchenko, G. M. Mustafina, N. V. Roiko, B. M. Filenko, S. A. Proskurnia |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The paper was aimed at the study of the features of the structural organization of the covering epithelium of the mucous membrane of dorsal surface of the tongue of albino rats under the conditions of consumption of complex of food additives, supplemented into the ration, for 4 weeks. The study was performed on 30 outbred albino rats, both male and female, weighing 204±0.67 g. The standard ration of the experimental animals was supplemented with a complex of food additives: monosodium glutamate, Ponceau 4R and sodium nitrite for 1 and 4 weeks. The analysis of the structure of the epithelium of the mucous membrane of the tongue was performed on the conventional histological specimens and semi-thin sections. It has been established that consumption of complex of food additives supplemented into the standard ration of white rats for 4 weeks leads to a progressive thickening of the stratified squamous epithelium of the entire dorsal surface of the tongue and is accompanied by hydropic dystrophy, acanthosis, hyperkeratosis, focal stratification disorder. |
| Tags |
food additives, mucous membrane, stratified squamous epithelium, the tongue, albino rats |
| Bibliography |
- Bahrii MM, Dibrova VA, Popadynets OH, Hryshchuk MI. Metodyky morfolohichnykh doslidzhen. Vinnytsia: Nova knyha; 2016. 328 s. [in Ukrainian]
- Vakhniuk TV. Histolohiya z tekhnikoyu histolohichnykh doslidzhen. Kyiv: VSV “Medytsyna”; 2018. 256s. [in Ukrainian]
- Gordiyenko LP, YeroshenkoGA, NeporadaKS. Osoblyvosti morfologichnykh zmin v slynnykh zalozakh shchuriv za umov glutamatindukovanoho ozhyrinnya. Svit medytsyny ta biologiyi. 2015;2(49):92–94. [in Ukrainian]
- Koka VM, Starchenko II, Mustafina HM, RoikoNV. Suchasni pohliady na funktsionalnu morfolohiyu slyzovoyi obolonky yazyka ta yiyi zminy za umov somatychnykh zakhvoriuvan ta vplyvu okremykh ekzohennykh poliutantiv. Visnyk problem biolohii i medytsyny. 2019;1(3):27–30. [in Ukrainian]
- Koka VM, Starchenko II, Roiko NV, Mustafina HM, Fylenko BM. Morfometrychna kharakterystyka myaziv yazyka za umov kombinovanoho vplyvu kharchovykh dobavok v eksperymenti. Aktualni problemy suchasnoyi medytsyny. 2021;21(4):148–52. Doi: 10.31718/2077–1096.21.4.148 [in Ukrainian]
- Medytska AK, Yeroshenko GA. Strukturni osoblyvosti slyzovoyi obolonky kinchyka yazyka shchuriv pislya diyi 1 % efiru metakrylovoyi kysloty. Visnyk problem biologiyi i medytsyny. 2019;3(152):300–303. [in Ukrainian]
- Panasiuk YeM, Zaiachkivska OS. Yazyk: klinichni ta fiziolohichni osnovy linhvodiahnostyky. Lviv: Svit; 2000. 56 s. [in Ukrainian]
- Poryadok provedennya naukovymy ustanovamy doslidiv, eksperymentiv na tvarynakh. Ofitsiynyy visnyk Ukrayiny. Ofits. vyd. 2012. (24): 82s. (Normatyvnyi dokument Ministerstva osvity, nauky, molodi ta sportu Ukrayiny. Nakaz vid 01.03.2012 № 249). [in Ukrainian]
- Skrypnykov PM. Vikovi osoblyvosti anatomiyi slyzovoi obolonky orhaniv porozhnyny rota: znachennia v diahnostychnomu protsesi. Visnyk problem biolohiyi i medytsyny. 2016;1(2):261–6. [in Ukrainian]
- Dursun A, Kastamonı Y, Kacaroglu D, Yuzbasıoglu N, Ertekın T. Morphometric development of the tongue in fetal cadavers. Surg Radiol Anat. 2020 Jan;42(1):3–8. doi: 10.1007/s00276-019-02301-z. Epub 2019 Aug 10. PMID: 31401676.
- Garcia Martins RH, Marques Madeira SL, Fabro AT, Rocha Nde S, de Oliveira Semenzati G, Alves KF. Effects to exposure of tobacco smoke and alcohol on the tongue and pharynx of rats. Inhal Toxicol. 2012;24(3):153–60. doi: 10.3109/08958378.2011.649190. Epub 2012 Feb 10. PMID: 22324907.
- Gunnars K. Are Nitrates and Nitrites in Foods Harmful? Healthline [updated Febr 10, 2020; cited 2020 Nov 24]. Available from: nitrates and nitrites harmful https://www.healthline.com/nutrition.
- Mangge H, Summers K, Almer G, Prassl R, Weghuber D, Schnedl W, et al. Antioxidant food supplements and obesity-related inflammation. Current Medicinal Chemistry. 2013; 20(18):2330–7. Doi: 10.2174/0929867311320180004.
- Seeker P, Osswald S. Tongue Discoloration. N Engl J Med. 2021;384(25):e102. doi: 10.1056/NEJMicm2100706.
- Yeroshenko GA, SemenovaAK. Structural features of the tongue dorsum mucosa in rats after the methacrylate effect. World of medicine and biology.2018;3(65):146–149. DOI 10.26724/2079-8334-2018-3-65-146-149
|
| Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 200-204 pages, index UDK 616-091 |
| DOI |
10.26724/2079-8334-2022-1-79-200-204 |
