| About the author: |
G. A. Yeroshenko, A. S. Grygorenko, K. V. Shevchenko, O. D. Lysachenko, O. B. Riabushko, N. M. Pyvovar, O. V. Klepets |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The study presents the findings of the study of the effect of food additives, namely, monosodium glutamate, sodium nitrite and Ponceau-4R on the morphological state of the components of the villi of the rats’ duodenal mucosa. The study was aimed at establishing the dynamics of changes in the metric parameters of the components of the villi of rats’ duodenal mucosa in normal conditions and under the action of the complex of food additives. It has been found that consumption of the complex of food additives leads to changes in the metric values of the height and width of the villi, which at the early stages of the experiment leads to a decrease in their mean values due to the immediate direct action on the mucous membrane with subsequent development of inflammatory reaction and edema, which will lead to an increase in metric values and a decrease in the number of epithelial cells of the villus. Adaptive mechanisms do not fully restore the values of the morphometric study, which is manifested by a decrease in the height of the villi by 20.25 % compared with the control group with an increase in the number of enterocytes with brush border and a decrease in the number of goblet cells by 44.41 %. |
| Tags |
food additives, duodenum, villus, mucous membrane, rats |
| Bibliography |
- Bilash SM, Donchenko SV. Morfofunktsionalnyi stan nadnyrnykiv pry dii kompleksu kharchovykh dobavok. Visnyk problem biolohii i medytsyny. 2020; 3(157): 13-19. [in Ukrainian].
- Lapach SN, Chubenko AV, Babych PN. Statystycheskye metodі v medyko-byolohycheskykh yssledovanyiakh s yspolzovanyem Exel. Kyev: Moryon. 2000; 320 s. https://www.twirpx.com/file/223261/ [in Russian].
- Petenkova AA, Kovalenko RY, Nozdrachev AD. Rol oksyda azota v formyrovanyy adaptyvnіkh reaktsyi leikotsytov u krіs pry nytrytnoi yntoksykatsyy. Rossyiskyi fyzyolohycheskyi zhurnal ym. YM Sechenova. 2017;103(7):789-98. [in Russian].
- Rutska AV, Getsko NV, Krynytska IYa. Toksychnyy vplyv glutamatu natriyu na zhyvyy organizm. Medychna ta klinichna khimiya. 2017; 19(1): 123-27.http://dx.doi.org/10.11603/mcch.2410-681X.2017.v0.i1.7685 [in Ukrainian].
- Sukhomlyn AA, Hordiienko LP, Mykytenko AO, Neporada KS, Berehova TV. Vplyv patolohichnykh protsesiv u orhanakh travnoho traktu na metabolichni protsesy u slynnykh zalozakh. Pivdennoukrainskyi medychnyi naukovyi zhurnal. 2018; 21(21): 44–49. [in Ukrainian].
- Elsherbiny NM, Maysarah NM, El-Sherbiny M, Al-Gayyar MM. Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis. Life Sci. 2017; 180: 1-8. http://dx.doi.org/ 10.1016/j.lfs.2017.05.005
- Feketea G, Tsabouri S. Common food colorants and allergic reactions in children: Myth or reality? Food Chem. 2017 Sep 1; 230: 578-588. http://dx.doi.org/10.1016/j.foodchem.2017.03.043
- Gerasimidis K, Bryden K, Chen X, Papachristou E, Verney A, Roig M, et al. The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fiber fermentation capacity. Eur J Nutr. 2020; 59(7): 3213-30. http://dx.doi.org/10.1007/s00394-019-02161-8
- Halim J, Bouzari A, Felder D, Guinard J.-X. The Salt Flip: Sensory mitigation of salt (and sodium) reduction with monosodium glutamate (MSG) in “Better-for-You” foods. Journal of Food Science. 2020; 85(9): 2902-14. http://dx.doi.org/10.1111/1750-3841.15354
- Kiani A, Yousefsani BS, Doroudian P, Seydi E, Pourahmad J. The mechanism of hepatotoxic effects of sodium nitrite on isolated rat hepatocytes. Toxicol Environ Health Sci. 2017;9(3):244-50. http://dx.doi.org/10.1007/s13530-017-0327-z
- Oplatowska-Stachowiak M, Elliott CT. Food colors: Existing and emerging food safety concerns. Crit Rev Food Sci Nutr. 2017; 57(3): 524-48. http://dx.doi.org/10.1080/10408398.2014.889652
- Pronina OM, Koptev MM, SM Bilash SM, Yeroshenko GA. Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data. World of medicine and biology. 2018; 1(63): 153-57. http://dx.doi.org/10.26.724/2079-8334-2018-1-63-153-157
- Savitsky IV, Kryukovа GV, Myastkivska IV. Еndothelial dysfunction due to sodium nitrite. Journal of Education, Health and Sport. 2020; 10(3): 188-98. http://dx.doi.org/10.12775/JEHS.2020.10.03.021
- Shevchenko KV, Yeroshenko GA, Yakushko OS, Kazakova KS, Kramarenko DR. Morphometric description of the exchange segment of microvasculature of rats’ salivary glands in normal conditions and chronic ethanol intoxication. Wiadomości Lekarskie. 2019; 72(3): 323-26. https://wiadlek.pl/wp-content/uploads/2020/01/WL-3-2019.
- Yachmin АІ, Kononov BS, Yeroshenko GА, Bilash SМ, Bilash VP. A measure of the effect of complex food additives on rats’ adaptive responses. World of medicine and biology. 2020; 1(71): 232-35. http://dx.doi.org/10.26724/2079-8334-2020-1-71-232-235
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| Publication of the article |
«World of Medicine and Biology» №2(80), 2022 year, 199-203 pages, index UDK 616.342:613.2:599.323.4 |
| DOI |
10.26724/2079-8334-2022-2-80-199-203 |
