| About the author: |
Н. M. Mustafina, I. I. Starchenko, V. М. Koka, B. М. Fylenko, N. V. Roiko, V. V. Cherniak, O. K. Prylutskyi |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of this study was to study in an experiment the morphological features of the structural organization of the periportal connective tissue of the liver of white rats after the introduction into the diet of a complex of food additives (sodium glutamate, sodium nitrite, Ponceau 4R) for 8 weeks. The study was performed on 30 outbred white rats of both sexes, weighing 204±0.67 g. The experimental animals were additionally fed a combination of food additives – monosodium glutamate, Ponceau R-4, sodium nitrate for 1 and 8 weeks. The study of the stromal component of the liver was carried out on traditional histological preparations. To differentiate immunocompetent cells of connective tissue structures, immunohistochemical reactions with antibodies to CD68 and CD3 were performed. It was established that the addition of a complex of food additives (sodium glutamate, sodium nitrite, ponzo 4R) to the standard diet of laboratory animals for 8 weeks leads to excessive development of connective tissue in the liver and changes in the relative number of CD3+ and CD68+ cellular elements. |
| Tags |
liver,connective tissue,stroma,food additives,monosodium glutamate,Ponceau R-4,sodium nitrate |
| Bibliography |
- Pro zakhyst tvaryn vid zhorstokoho povodzhennya: Zakon Ukrayiny vid 21.02.2006 No. 3447-IV: redaktsiya 08.08.2021. https://zakon.rada.gov.ua/laws/show/3447-15?find#Text/ [in Ukrainian]
- Binns CW, Lee MK, Lee AH. Problems and Prospects: Public Health Regulation of Dietary Supplements. Annual Review of Public Health. 2018; 39(1): 403–420 DOI 10.1146/annurev-publhealth-040617-013638.
- Koka VM, Starchenko II, Mustafina НM, Roiko NV, Filenko BM, Proskurnia SA. Features of the structure of the epithelium of the mucous membrane of the tongue under the effect of complex of food additives in the experiment. World of medicine and biology. 2022;1(79):200–204. DOI 10.26724/2079-8334-2022-1-79-200-204.
- Magee N, Zou A, Zhang Y. Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells. BioMed Research International. 2016;2016:5170402. DOI 10.1155/2016/5170402/
- Mega A, Marzi L, Kob M, Piccin A, Floreani A. Food and Nutrition in the Pathogenesis of Liver Damage. Nutrients. 2021;13(4):1326. DOI 10.3390/nu13041326.
- Mustafina HM, Starchenko II, Fylenko BМ, Koka VM, Cherniak VV, Roiko NV, Proskurnya SA. Morphological features of the liver parenchyma in the experimental supplementation of ration with the food additives. Wiadomości Lekarskie. 2022; LXXV(6):1525–1528. DOI 10.36740/WLek202206117.
- Xu L, Liu W, Bai F, Xu Y, Liang X, Ma C and Gao L. Hepatic Macrophage as a Key Player in Fatty Liver Disease. Frontiers in Immunology. 2021;12: 708978. DOI 10.3389/fimmu.2021.708978. PMID: 34956171
- Sanz-García C, Fernández-Iglesias A, Gracia-Sancho J, Arráez-Aybar LA, Nevzorova YA, Cubero FJ. The Space of Disse: The Liver Hub in Health and Disease. Livers. 2021; 1(1):3–26. doi.org/10.3390/livers1010002.
- Thiele M, Johansen S, Gudmann NS, Madsen B, Kjaergaard M, Nielsen MJ, et al. Progressive alcohol-related liver fibrosis is characterised by imbalanced collagen formation and degradation. Alimentary pharmacology and therapeutics. 2021;54(8):1070–1080. DOI 10.1111/apt.16567.
- Torres Rojas AM, Lorente S, Hautefeuille M, Sanchez-Cedillo A. Hierarchical Modeling of the Liver Vascular System. Frontiers in physiology. 2021;12: 733165 DOI 10.3389/fphys.2021.733165.
- Trefts E, Gannon M, Wasserman DH. The liver. Current Biology. 2017;27(21): 1147–1151. DOI 10.1016/j.cub.2017.09.019.
- Vilas-Boas V, Gijbels E, Jonckheer J, De Waele E, Vinken M. Cholestatic liver injury induced by food additives, dietary supplements and parenteral nutrition. Environment international. 2020;136: 105422. DOI 10.1016/j.envint.2019.105422.
- WMA Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjects. http://www.wma.net.
- Yeroshenko GА, Yachmin АІ, Shevchenko KV. Lysachenko OD, Riabushko OB, Sokolenko VM. Sharlai NM. Morphological and metric changes of the glandular apparatus of the rat stomach fundus under the effect of a complex of food additives. World of medicine and biology. 2022;1(79):189–194.
- Zinöcker MK, Lindseth IA. Rettelse: Tilsetningsstoffer – er vi føre var? [Correction: Food additives – are we better off safe than sorry?]. Tidsskrift for den Norske laegeforening: tidsskrift for praktisk medicin, ny raekke. 2020;140(4). DOI 10.4045/tidsskr.20.0104. [in Norwegian]
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| Publication of the article |
«World of Medicine and Biology» №3(81), 2022 year, 227-230 pages, index UDK 616.36:641:612.08 |
| DOI |
10.26724/2079-8334-2022-3-81-227-230 |
