| About the author: |
R. V. Martynenko, V. I. Shepitko, L. B. Pelypenko, N. V. Boruta, V. B. Martynenko, O. V. Vilhova, Y. V. Stetsuk |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Prostate cancer is the most common cancer diagnosis among men, with more than 160,000 new cases each year in the United States. Huggins and Hodges demonstrated the therapeutic effect of testosterone deficiency in the gonads in the 1940s and thus confirmed the concept that prostate cancer is an androgen-dependent disease. Androgen deprivation therapy (ADT) is the main palliative treatment for men with locally advanced and metastatic prostate cancer, with the goal of reducing testosterone levels to the level obtained by surgical castration. The long-term chemical castration with triptorelin acetate leads to quantitative and qualitative changes in monocytic sprout cells at all levels of differentiation and proliferation with a complementary reaction of microenvironmental cells. The maximum quantitative changes in monocyte cells were observed at the 3rd month of the study, followed by a gradual recovery to the control group. Changes in the microenvironment cells: macrophages and reticular cells, were characterized by a stable reaction in the early stages of the study in the form of a decrease in the number and ratio of NSCs, with subsequent recovery of quantitative and qualitative changes to the level of the control group of animals. The adipocyte reacts at all stages of the study with a steady increase in quantitative and qualitative characteristics. |
| Tags |
red bone marrow,monocytopoiesis,microenvironmental cells,triptorelin |
| Bibliography |
- Bahriy MM, Dibrova VA, editors. Metodyky morfolohichnykh doslidzhen. Vinnytsya: Nova knyha; 2016. 328s. [in Ukrainian]
- Martynenko RV. Vplyv tsentralnoyi depryvatsiyi testosteronu na strukturnu orhanizatsiyu monotsytarnoho klonu chervonoho kistkovoho mozku v ranni terminy eksperymentu. Aktualni problemy suchasnoyi medytsyny. 2021; 21, 2 (74). doi 10.31718/2077-1096.21.2.142. [in Ukrainian]
- Albadrani GM, Binmowyna MN, Bin-Jumah MN, El-Akabawy G, Aldera H, Al-Farga AM. Quercetin protects against experimentally-induced myocardial infarction in rats by an antioxidant potential and concomitant activation of signal transducer and activator of transcription. J Physiol Pharmacol. 2020 Dec; 71(6): 125–7. doi: 10.26402/jpp.2020.
- Başak Ar, Tuba A, Hüsniye D, Gizem G, Gülderen YD. Testosterone propionate promotes proliferation and viability of bone marrow mesenchymal stem cells while preserving their characteristics and inducing their anti-cancer efficacy. Balkan Med JFeb 7. doi: 10.4274/balkanmedj.galenos.2022.2022-10-21.
- Botté MC, Lerrant Y, Lozach A, Bérault A, Counis R, Kottler ML. LH down-regulates gonadotropin-releasing hormone (GnRH) receptor, but not GnRH, mRNA levels in the rat testis. J Endocrinol. 1999; 162(3): 40915. doi:10.1677/joe.0.1620409.
- Desai K, McManus JM, Sharifi N. Hormonal Therapy for Prostate Cancer. Endocrine Reviews. Volume 42, Issue 3, June 2021, Pages 354–373. doi: 10.1210/endrev/bnab002.
- Huang C, Pang H, Wang L, Niu Y, Luo J, Chang E, et al. New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis. Hypertension. 2014 Jun;63(6):1345–53. doi: 10.1161/ HYPERTENSIONAHA.113.02804.
- Jorgensen TN, Kovats S, Lotter H. Effects of Androgens on Immunity to Self and Foreign. Frontiers in Immunology. 2020; 11:3476. doi: 10.3389/fimmu.2020.630066.
- Litwin MS, Tan H. The Diagnosis and Treatment of Prostate Cancer: A Review. JAMA. 2017;317(24):2532–2542. doi:10.1001/jama.2017.7248.
- Lucas D. Structural organization of the bone marrow and its role in hematopoiesis. Current Opinion in Hematology 28(1): 36–42, January 2021. doi: 10.1097/MOH.0000000000000621.
- Merseburger, AS, Hupe MC. An Update on Triptorelin: Current Thinking on Androgen Deprivation Therapy for Prostate Cancer. Adv Ther. 2016; 33, 1072–1093. doi: 10.1007/s12325-016-0351-4.
- Ohlander SJ, Varghese B, Pastuszak AW. Erythrocytosis following testosterone. Therapy Sex Med Rev. 2018 Jan;6(1):77–85. doi:10.1016/j.sxmr. 2017.04.001.
- Reyes-García J, Montaño LM, Carbajal-García A, Wang YX. Sex Hormones and Lung Inflammation. In: Wang, YX. (eds) Lung Inflammation in Health and Disease, Volume II. Advances in Experimental Medicine and Biology. 2021; 1304. Springer, Cham. doi: 10.1007/978-3-030-68748-9_15.
- Rud MV, Shepitko VI, Stetsuk YeV, Akimov OYe, Vilkhova OV, Skotarenko TA. The reaction of immunocompetent liver cells during chemical castration of male rats caused by the introduction of triptorelin acetate. World of Medicine and Biology. 2021. № 2 (76): 238–242. doi: 10.26724/2079-8334-2021-2-76-238-242.
- Woods GN, Ewing SK, Sigurdsson S, Kado DM. Greater bone marrow adiposity predicts bone loss in older women. J Bone Miner Res. 2020 Feb;35(2):326–332. doi: 10.1002/jbmr.3895.
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| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 214-218 pages, index UDK 611.018.46:615.21/27:612.08 |
| DOI |
10.26724/2079-8334-2023-1-83-214-218 |
