| About the author: |
Y. M. Hurtova, O. V. Dienha, A. E. Dienga, K. V. Litovkin, T. O. Pyndus, V. B. Pyndus, S. A. Shnaider |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Osteopenia is a complex disease associated with decreased bone mineral density and characterized by a moderate risk of fracture, which in certain situations can lead to osteoporosis. Identification of predisposition factors for osteopenia may help to individualize prognosis, treatment, and prevention of fractures and their adverse outcomes. The purpose of this study was to examine the association of single-nucleotide polymorphisms of the TNFSF11, TNFRSF11B, SOST, ZNF385B, and LRP5 genes involved in bone metabolism and Porphyromonas gingivalis oral infection with risk for osteopenia. The study group included 18 patients with osteopenia. The control group included 18 people without osteopenia. The T-allele polymorphism of the TNFRSF11B gene increased the risk of osteopenia in allelic, dominant, and recessive inheritance models, while the A-allele polymorphism of the ZNF385B gene – in allelic and dominant inheritance models. The number of bacteria in the gingival sulcus fluid samples of patients with osteopenia significantly exceeded the same indicator in the control group |
| Tags |
osteopenia,oral health,polymorphism,genotyping,oral bacteria |
| Bibliography |
- Lang TA, Sesik M. Kak opisyvat statistiku v meditsine. Moskva: Prakticheskaya meditsina. 2016; 480. [in Russian]
- Abdi S, Binbaz RA, Mohammed AK, Ansari MGA, Wani K, Amer OE, et al. Association of RANKL and OPG Gene Polymorphism in Arab Women with and without Osteoporosis. Genes (Basel). 2021 Jan 29;12(2):200. doi: 10.3390/genes12020200.
- Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M, et al. Zinc-finger proteins in health and disease. Cell Death Discov. 2017 Nov 13; 3:17071. doi: 10.1038/cddiscovery.2017.71.
- Jiang Y, Song B, Brandt BW, Cheng L, Zhou X, Exterkate RAM, et al. Comparison of Red-Complex Bacteria Between Saliva and Subgingival Plaque of Periodontitis Patients: A Systematic Review and Meta-Analysis. Front Cell Infect Microbiol. 2021; 11:727732. doi: 10.3389/fcimb.2021.727732.
- Kassem A, Henning P, Lundberg P, Souza PP, Lindholm C, Lerner UH. Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-κB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts. J Biol Chem. 2015;290(33):20147–58. doi: 10.1074/jbc.M115.655787.
- Kostyrenko ОP, Melnyk VL, Shevchenko VK, Sylenko YuI, Yeroshenko GA. Application of nanocrystals in treatment of chronic apical periodontitis. World of Medicine and Biology. 2020;3(73):61–65. doi: 10.26724/2079-8334-2020-3-73-61-65.
- Lin J, Huang D, Xu H, Zhan F, Tan X. Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases. Front Immunol. 2022; 13:952040. doi: 10.3389/fimmu.2022.952040.
- Nazir M, Al-Ansari A, Al-Khalifa K, Alhareky M, Gaffar B, Almas K. Global Prevalence of Periodontal Disease and Lack of Its Surveillance. Scientific World Journal. 2020; 2020:2146160. doi: 10.1155/2020/2146160.
- Oton-Gonzalez L, Mazziotta C, Iaquinta MR, Mazzoni E, Nocini R, Trevisiol L, et al. Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases. Int J Mol Sci. 2022 Jan 28;23(3):1500. doi: 10.3390/ijms23031500.
- Qian BP, Wang XQ, Qiu Y, Jiang J, Ji ML, Feng F. Association of receptor activator of nuclear factor-kappaB ligand (RANKL) gene polymorphisms with the susceptibility to ankylosing spondylitis: a case-control study. J Orthop Sci. 2014;19(2):207–212. doi: 10.1007/s00776-013-0528-5.
- Walsh PS, Metzger DA, Higushi R. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques. 2013 Mar;54(3):134–9. doi: 10.2144/000114018.
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| Publication of the article |
«World of Medicine and Biology» №2(84), 2023 year, 055-059 pages, index UDK [616-036+575.1]:616.71-008.5 |
| DOI |
10.26724/2079-8334-2023-2-84-55-59 |
