| About the author: |
G. Z. Faragzheva |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to assess the epidemiological condition and clinical course of true acantholytic pemphigus in Azerbaijan. 554 patients with true acantholytic pemphigus were involved in observation. We analyzed the dynamics in morbidity (coverage of a period from 1999 to 2011). It was found that there was a steady increase in the morbidity since 1999, and since 2006 the rate of disease growth has formed 6-year cycle. The course of the disease has changed, it has become more severe and resistant to the therapy. The number of patients with true acantholytic pemphigus increased in persons under 40 years of age (where there was a twofold predominance of women). The prevalence of common forms over limited, a reduction in the period of mucosal lesions, rejuvenation of the disease’s formation, resistance of the disease to the therapy (a twofold increase in the dose of glucocorticoids) make it possible to make judgments about the change in the course of the disease. |
| Tags |
true acantholytic pemphigus,epidemiology,resistance to therapy,morbidity |
| Bibliography |
- Celere BS, Vernal S, Brochado MJF, Segura-Muñoz SI, Roselino AM. Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil. Int J Dermatol. 2017 Dec;56(12):1494–1496. doi: 10.1111/ijd.13714.
- Egu DT, Schmitt T, Waschke J. Mechanisms Causing Acantholysis in Pemphigus-Lessons from Human Skin. Front Immunol. 2022 May 20; 13:884067. doi: 10.3389/fimmu.2022.884067.
- Furue M, Kadono T. Pemphigus, a pathomechanism of acantholysis. Australas J Dermatol. 2017 Aug;58(3):171–173. doi: 10.1111/ajd.12562.
- Helm M, Helm LA, Clebak KT, Foulke G. Autoimmune Skin Conditions: Autoimmune Blistering Disease. FP Essent. 2023 Mar; 526:13–17. PMID: 36913658.
- Ingold CJ, Sathe NC, Khan MAB. Pemphigus Vulgaris. [Updated 2024 Mar 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560860.
- Jelti L, Cordel N, Gillibert A, Lacour JP, Uthurriague C, Doutre MS, et al. Incidence and mortality of pemphigus in France. J Invest Dermatol. 2019; 139:469–473. doi: 10.1016/j.jid.2018.07.042.
- Kasperkiewicz M, Schmidt E, Fairley JA, Joly P, Payne AS, Yale ML, et al. Expert recommendations for the management of autoimmune bullous diseases during the COVID-19 pandemic. J Eur Acad Dermatol Venereol. 2020 Jul;34(7): e302-e303. doi: 10.1111/jdv.16525.
- Kridin K, Ahn C, Huang WC, Ansari A, Sami N. Treatment Update of Autoimmune Blistering Diseases. Dermatol Clin. 2019 Apr;37(2):215–228. doi: 10.1016/j.det.2018.12.003.
- Kridin K, Schmidt E. Epidemiology of Pemphigus. JID Innov. 2021 Feb 20;1(1):100004. doi: 10.1016/j.xjidi.2021.100004.
- Li X, Zhang L, Gu H, He W, Zhai Z, Zhang M. Treatment and molecular analysis of bullous pemphigoid with tofacitinib: a case report and review of current literature. Front Immunol. 2024 Oct 21; 15:1464474. doi: 10.3389/fimmu.2024.1464474.
- Ohzono A, Sogame R, Li X, Teye K, Tsuchisaka A, Numata S, et al. Clinical and immunological findings in 104 cases of paraneoplastic pemphigus. Br J Dermatol. 2015; 173:1447–1452. doi: 10.1111/bjd.14162.
- Patel F, Wilken R, Patel FB, Sultani H, Bustos I, Duong C, et al. Pathophysiology of Autoimmune Bullous Diseases: Nature Versus Nurture. Indian J Dermatol. 2017 May-Jun;62(3):262–267. doi: 10.4103/0019-5154.159620.
- Porro AM, Seque CA, Ferreira MCC, Enokihara MMSES. Pemphigus vulgaris. An Bras Dermatol. 2019 Jul 29;94(3):264–278. doi: 10.1590/abd1806-4841.20199011.
- Schmidt E, Kasperkiewicz M, Joly P. Pemphigus. Lancet. 2019 Sep 7;394(10201):882–894. doi: 10.1016/S0140-6736(19)31778-7.
- Xie D, Bilgic A, Abu Alrub N, Dicle Ö, Murrell DF. Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study. JAAD Int. 2022 Oct 11; 10:6–13. doi: 10.1016/j.jdin.2022.08.025.
|
| Publication of the article |
«World of Medicine and Biology» №4(90), 2024 year, 135-138 pages, index UDK 616.527-06-085 |
| DOI |
10.26724/2079-8334-2024-4-90-135-138 |
