| About the author: |
Sh. G. Ismayilova, Sh. S. Ibrahimova, S. R. Muradova, E. I. Haziyev, L. Kh. Safaraliyeva, A. N. Humbatova, A. P. Mammadova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
This study aimed to assess the association of the endothelial nitric oxide synthase 786T>C (rs2070744) and 894G>T (rs1799983) polymorphisms with end-stage renal disease risk in an Azerbaijani cohort. The study included 120 end-stage renal disease patients and 100 healthy controls. The results revealed that the T allele of the endothelial nitric oxide synthase 786T>C polymorphism significantly increased the risk of end-stage renal disease (p=0.002). Moreover, the T allele in both the endothelial nitric oxide synthase 786T>C and 894G>T polymorphisms was associated with a higher risk of macroalbuminuria (OR=5.93; p=0.013) and microalbuminuria (OR=2.56; p=0.024). These findings suggest that the T alleles in the endothelial nitric oxide synthase polymorphisms play a crucial role in chronic kidney disease progression, and genetic screening for these variants may help identify patients at greater risk for end-stage renal disease in Azerbaijani population. |
| Tags |
chronic kidney diseases,eNOS gene polymorphisms,T-786C,G894T,end-stage renal disease |
| Bibliography |
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| Publication of the article |
«World of Medicine and Biology» №1(91), 2025 year, 061-064 pages, index UDK 616.61-036.12-053.2 |
| DOI |
10.26724/2079-8334-2025-1-91-61-64 |
