| About the author: |
O. Y. Akimov, A. O. Mykytenko, V. O. Kostenko, G. A. Yeroshenko |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Oxidative stress is a typical pathological process, which underlies development of many diseases. Metabolic syndrome disrupts physiological supply of metabolites to the cell leading to energy deficiency, due to low grade inflammation development, and oxidative stress, caused by mitochondria impairment. It has been already shown that redox sensitive transcriptional factors like NF-κB play a crucial role in pathogenesis of metabolic syndrome and its complications. At the same time, there are few mentions of role of mitogenic cycle controlling factors such as p38-MAPK cascade in pathogenesis of metabolic syndrome. The purpose of the study was to evaluate influence of SB203580 administration on production of superoxide anion radical, activities of antioxidant enzymes, intensity of lipid peroxidation and protein damage in rat biceps femoris muscle during metabolic syndrome modeling. Studied basic superoxide anion radical production, its production from microsomal electron transport chain, its production from mitochondrial electron transport chain, superoxide dismutase and catalase activity, concentration of malondialdehyde and oxidatively modified proteins. SB203580 administration to animals, on which we modeled metabolic syndrome, led to decrease in basic superoxide production in rat biceps femoris muscle by 25.7 % compared to metabolic syndrome group. Superoxide anion radical production from microsomal electron transport chain decreased by 16.0 % and from mitochondrial electron transport chain decreased by 14.6 % compared to indicators of metabolic syndrome group. SB203580 administration to animals, on which we modeled metabolic syndrome, increased superoxide dismutase and catalase activities by 93.1 % and by 98.4 %, respectively, compared to metabolic syndrome group. Concentration of malondialdehyde and oxidatively modified proteins in rat biceps femoris muscle decreased by 21.1 % and by 22.8 % compared to metabolic syndrome group. Administration of SB203580 attenuates oxidative stress development in rat biceps femoris muscle during metabolic syndrome by decreasing reactive oxygen species production, increasing antioxidant defense and lowering intensity of lipid and protein damage. |
| Tags |
skeletal muscles,oxidative stress,antioxidants,metabolic syndrome,carbonyl stress,p38,MAPK |
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| Publication of the article |
«World of Medicine and Biology» №2(92), 2025 year, 146-149 pages, index UDK 617.587:616.74:616-008:599.323.4 |
| DOI |
10.26724/2079-8334-2025-2-92-146-149 |
